Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The distribution and the kinetics of potentiated antibody synthesis have been studied at the cellular level in rats infested with Nippostrongylus brasiliensis using the homologous adoptive cutaneous anaphylaxis technique. In animals immunized in the hind footpads with alum-absorbed ovalbumin 10 days prior to infestation with the parasite, the major sites of potentiated anti-ovalbumin homocytotropic antibody synthesis were the regional lymph nodes of the gut and the lungs. Peyer's patches were weakly active late in the response and the spleen produced considerable amounts of potentiated antibody. The regional lymph nodes of the ovalbumin immunization sites were the only organs in which specific homocytotropic antibody synthesis was detected in uninfested control rats. The kinetics of synthesis of the potentiated antibody by cells correlated well with the levels of anti-ovalbumin IgE antibodies in the sera of the infested rats. A traffic of cells secreting anti-ovalbumin homocytotropic antibody was detected in the thoracic duct lymph, but not the mesenteric lymph of immunized uninfested rats. After infestation, the mesenteric lymph also contained cells secreting potentiated antibody. The mesenteric lymph is a major route by which IgE and potentiated IgE antibodies reach the circulation in infested rats. The possible mechanisms responsible for the effects of the parasite on antibody secretion in distant lymphoid organs are discussed.
 ...
PMID:Potentiated IgE response in Nippostrongylus brasiliensis infested rats--sites of synthesis and traffic of cells secreting potentiated antibody. 375 62

Enzyme-linked immuno-filtration assay is carried out on a micropore membrane. This doubly analytical technique permits simultaneous study of antibody specificity by immunoprecipitation and characterisation of antibody isotypes by immuno-filtration with enzyme-labelled antibodies. Recognition of the same T. gondii antigenic constituent by IgG, IgA, IgM or IgE antibodies produces couplets (IgG-IgM; IgG-IgA) or triplets (IgG-IgM-IgA; IgG-IgM-IgE) which identify the functional fractions of the toxoplasmosis antigen. In acquired toxoplasmosis, the persistence of IgM antibody long after infestation puts in question the implication of recent infestation normally linked to detection of this isotype. For sera of comparable titres, comparison of immunological profiles by the method described demonstrates disparities in the composition of the specific antibody content as expressed in international units. Use of the same method to detect IgM antibodies or distinguish between transmitted maternal IgG and IgG antibodies synthesised by the foetus or neonate makes a diagnosis of congenital toxoplasmosis possible in 85% of cases during the first few days of life. With the method described the diagnosis may be made on average 5 months earlier than with classical techniques. In the course of surveillance for latent congenital toxoplasmosis, the appearance of IgM or IgE antibodies raises the possibility of complications (hydrocephalus, chorioretinitis). After cessation of treatment, a rise in IgG antibodies indicating persistence of infection is detected earlier by the present than by classical methods.
 ...
PMID:An enzyme-linked immuno-filtration assay used to compare infant and maternal antibody profiles in toxoplasmosis. 388 43

The effects of Onchocerca volvulus infection on immunoglobulin levels have been studied in subjects from three localities with different onchocerciasis prevalence rates. Infestation by O. volvulus provoked a 200-500% rise in total serum IgE levels. Immunoglobulins G, M. and A were increased less dramatically. To study further the IgE response, radioallergosorbent test (RAST) systems were developed using total extract of O. volvulus and Onchocerca supernatant (excretory-secretory) antigens. Both antigen preparations reacted with more than 80% of the onchocerciasis sera from the hyperendemic village, but the reactions were not proportionate to skin microfilarial density. There were also positive reactions with sera of some individuals whose skin biopsies showed no microfilariae, indicating prior exposure to the parasite. European control sera tested under similar conditions reacted only slightly in the RAST system. The developed RAST systems may thus be used for determining prior exposure to O. volvulus.
 ...
PMID:Serum immunoglobulin E levels in onchocerciasis: the development of a radioallergosorbent test for Onchocerca volvulus infection. 400 65

Animals from two inbred rat strains, Brown Norway (BN) and WAG, expressing high and low-IgE-responder phenotype, respectively, were sensitized to ovalbumin (OV) while parasitized with the intestinal helminth Nippostrongylus brasiliensis (Nb). The animals were challenged intradermally and intravenously with OV, and the severity of their immediate hypersensitivity responses was compared to those of non-parasitized OV-immune controls. Nb infestation depressed hypersensitivity responses in the low-IgE-responder WAG rats, but was without effect in high-IgE-responder BNs.
 ...
PMID:Suppression of allergic reactivity by intestinal helminths: susceptibility is a function of IgE responder phenotype. 405 84

Authors introduced as the first in Yugoslavia the method of isolation and classifying Dermatophagoides pteronyssinus out of house dust using the first the help of Spieksma, Cunnington and Araujo, later on by themselves in new established laboratory. In house dust of 290 houses of asthmatic children in 88 (30,8%) through of cases mites were found, mostly Dermatophagoides pteronyssinus. 212 asthmati children who did not react well to specific hyposensitisation with standard house dust extract showed an allergy to house dust mites in 76 (35,8%), who were successful treated with allergen extract Dermatophagoides pteronyssinus with the cutaneous method of hyposensitisation. House dust mites allergy has clinical importance in asthmatic children for pathogenesis of asthma bronchiale in childhood as well in adults. IgE values in the serum after the radioimmunological method in asthmatic and healthy children has been estimated. In asthmatic children we found statistical significant higher of IgE values in the serum as in healthy children, this is probably caused by the infestation from Ascaris lumbricoides. Asthmatic children were significant stengher infesteds the healthy children.
 ...
PMID:[Epidemiology, diagnosis and treatment of the house-dust-mite allergy in asthmatic children]. 428 21

Seven patients with gastrointestinal disorders and deficiencies of serum and secretory immunoglobulins were evaluated clinically, microbiologically, and immunologically. Five patients had generalized deficiencies of immunoglobulins; two were selectively deficient. Diarrhoea and malabsorption in six of the seven patients were at least partially explained. Four of the five patients with generalized hypogammaglobulinaemia had intestinal infestation with Giardia lamblia; in three of the five, excessive numbers of anaerobic bacteria were cultured from small bowel fluids. Despite much variability in relative severity of patients' respiratory and gastrointestinal tract symptoms, deficiencies of mucosal immunocytes and immunoglobulins in nasopharyngeal and gastrointestinal tract tissues and secretions were similar. Except for one selectively IgA-deficient patient, all patients were deficient in IgE. The study characterizes in greater detail than heretofore the gastrointestinal disorders associated with immunoglobulin deficiency states.
 ...
PMID:Clinical, microbiological, and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders. 455 6

The relationship between the IgE-mediated immunogenic response to Ascaris and similar responses to common inhaled allergens was determined. Sixty-six of 170 allergic asthmatics from an area in which Ascaris infestation was endemic had positive skin-prick reactions to Ascaris antigen. The number and size of skin-prick reactions to common inhaled allergens were greater in this group than in the 104 Ascaris-negative allergic asthmatics. Specific serum IgE antibodies were determined by the radio-allergosorbent test. The serum IgE levels for Ascaris and three common inhaled allergens correlated well with the skin reactions induced by the same antigens. Total IgE and serum IgE antibody levels for the three inhaled allergens were higher in patients who had positive results on skin testing with Ascaris antigen than in those with negative results. There was no similar association between Dermatophagoides pteronyssinus and six common inhaled allergens. An Ascaris-induced immune response was associated with enhanced IgE-mediated reactivity to common inhaled allergens in both allergic and clinically non-allergic subjects.
 ...
PMID:Ascaris lumbricoides and the human immunogenic response: enhanced IgE-mediated reactivity to common inhaled allergens. 615 96

The authors present a case of a 46 year old man without any past history of allergy, who presented with severe asthma of recent onset associated with moderate eosinophilia, a raised total IgE level and a Larva currens type of dermatitis. Serology and stool culture revealed anguillulosis. The negative DLAC and the fact that the asthma disappeared after treatment of the parasitic infestation suggest that it was related to the anguillulosis.
 ...
PMID:[Bronchial asthma associated with anguilluliasis]. 653 76

Mesenteric lymphadenectomy caused a marked reduction in the amounts of both parasite-specific and total IgE in the serum of Nippostrongylus brasiliensis infested rats. This was accompanied by reduced quantities of IgE in the thoracic duct lymph, showing that the mesenteric lymph node is of great importance in the generation of the elevated IgE levels which accompany this infestation. Conversely, the intestinal lamina propria and the Peyer's patches did not appear to be significant contributors to either thoracic duct lymph or serum IgE levels. Homocytotropic antibody-secreting cells specific for parasite antigens were detected in the thoracic duct lymph of lymphadenectomized rats and are believed to arise directly from the gut mucosa and possibly from Peyer's patches.
 ...
PMID:Origins of serum IgE and of the homocytotropic antibody-secreting cells in the thoracic duct lymph of rats infested with Nippostrongylus brasiliensis. 653 2

IgE levels after Nippostrongylus brasiliensis infestation were high in all strains of mice examined except in the SJA/9 strain. However, surface IgE levels on B cells were not different from those observed in the SJL strain. Most surface IgE-bearing cells also had surface IgM molecules. We suggest that the surface IgE-bearing cells are precursors of IgE-producing cells. In adoptive transfer, hapten-specific IgE antibody was produced when hapten-primed cells from SJA/9 mice were transferred together with cells from SJL donors infested with N. brasiliensis but not when the cells were from SJA/9 donors. It is suggested that the lack of collaboration between hapten-primed B cells and cells from infested mice is a genetic trait of the SJA/9 strain.
 ...
PMID:Studies on IgE production in mice. I. Spontaneous suppression of IgE production in SJA/9 mice. 660 21


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>