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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Strain-, sex- and age-based resistance of mice to Toxocara canis infection was demonstrated. Infection doses of similar numbers resulted in significantly (P less than 0.05) greater worm establishment in CD1 mice than in NIH mice, as well as a greater heterogeneity of responses between individuals. Male mice had significantly (P less than 0.05) fewer larvae in the brain and more larvae in the liver than female mice, when mice of greater than or equal to 3 months old were used. Appreciably more larvae were retained in the liver of male CD1 mice than in NIH mice. Orchidectomized mice had higher levels of brain infestation and a lower larval recovery from the liver compared with intact male mice. Infections in young mice of both strains showed more diversity in establishment and migration pattern between individuals than in older mice. Despite these differences in distribution of larvae and in the numbers recovered from experimental infections, the acute and chronic clinical signs observed in the two strains were very similar.
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PMID:Variations in innate resistance to experimental Toxocara canis infection in two strains of mice. 281 39

Immunohistochemical analysis of skin and draining lymph nodes of sheep repeatedly infested with the ixodid tick Hyalomma anatolicum anatolicum were studied for different antigen-presenting cells and lymphocyte subpopulations. Infiltration of neutrophils, macrophages and lymphocytes adjacent to the tick bite site were observed. Skin biopsies showed significant increases in dermal infiltration of CD8+ and gammadelta+ T cells at 72 h and 8 days after both primary and secondary infestation. Infiltrations of MHC-II DR/DQ decreased at 72 h after tick infestation, whereas significant increases were recorded for 8-day skin biopsies. CD1+ cellular infiltrations were observed during secondary infestations at the dermis. Decreased ratios of CD4:CD8 T cells and MHC-II:CD1 antigen-presenting cells were observed in both infestations compared to healthy skin biopsies. Ratios of alphabeta:gammadelta T cells increased gradually during infestation compared to uninfested skin. The regional lymph nodes from tick-infested sheep showed an increased CD8+, gammadelta+ T and CD1+ cellular infiltration compared to control lymph nodes. CD4+ T cells were decreased. There were no significant changes in CD45R+ cellular infiltration either at skin lesions or regional lymph nodes.
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PMID:Cellular infiltration at skin lesions and draining lymph nodes of sheep infested with adult Hyalomma anatolicum anatolicum ticks. 1625 24