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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Affinity purified antibodies to human collagen type I and III and antihuman fibronectin, were employed immunohistochemically on formalin-fixed, paraffin-embedded human tissue containing schistosome granulomata. The distribution of the three connective tissue proteins was studied in 45 biopsies in which there was Schistosoma haematobium (30) and Schistosoma mansoni (15) infestation. The granulomata were divided into early, intermediate and late according to the proportion of inflammatory cell types and the degree of fibrous tissue deposition. Only fibronectin was detected in the early granuloma where macrophages are the main cell type. In the intermediate granuloma both fibronectin and collagen type III were localized along reticulin positive fibres; spindle cells, (presumptive fibroblasts) and macrophages were the cell types present at this stage. Collagen type I was mainly localized in the late granuloma. Hyalinized connective tissue was negative for the three proteins. The loose connective tissue and walls of blood vessels were constantly stained for fibronectin and collagen type III in normal areas distant from granulomata. These results raise the possibility of using localization of fibronectin and collagen as a means to stage the duration of chronic fibrotic diseases.
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PMID:Concomitant immunohistochemical localization of fibronectin and collagen in schistosome granulomata. 390 66

The tick Rhipicephalus (Boophilus) microplus is a hematophagous ectoparasite that causes considerable economic losses to cattle breeding. Although R. microplus saliva contains several molecules that interfere with the blood coagulation process, so far the systemic alterations in the host hemostatic system have not been described. This study aims to determine if R. microplus infestation induces any disturbance to the host's hemostatic system. To address these questions, six calves were experimentally infested with 20,000 R. microplus larvae and their blood was collected before and 7, 14 and 21 days post-infestation. Collagen and ADP-induced platelet aggregation as well as coagulation (activated partial thromboplastin time and prothrombin time) decreased in infested bovines. Platelet blood count and fibrinogen increased during the course of infestation, probably as a compensatory response. These alterations may play a role in host health status, and show that the host cannot fully counteract the tick anti-hemostatic mechanisms.
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PMID:Systemic alterations of bovine hemostasis due to Rhipicephalus (Boophilus) microplus infestation. 1857 84