Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0851341 (
infestation
)
10,121
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
IgE levels after Nippostrongylus brasiliensis
infestation
were high in all strains of mice examined except in the
SJA
/9 strain. However, surface IgE levels on B cells were not different from those observed in the SJL strain. Most surface IgE-bearing cells also had surface IgM molecules. We suggest that the surface IgE-bearing cells are precursors of IgE-producing cells. In adoptive transfer, hapten-specific IgE antibody was produced when hapten-primed cells from
SJA
/9 mice were transferred together with cells from SJL donors infested with N. brasiliensis but not when the cells were from
SJA
/9 donors. It is suggested that the lack of collaboration between hapten-primed B cells and cells from infested mice is a genetic trait of the
SJA
/9 strain.
...
PMID:Studies on IgE production in mice. I. Spontaneous suppression of IgE production in SJA/9 mice. 660 21
