Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of several hundreds of millions of people infested with schistosomiasis, only a few hundreds have, so far, been documented to have one or other of the three schistosoma-associated immune-mediated glomerulopathies, namely proliferative glomerulonephritis, focal and segmental sclerosis, and amyloidosis. Regardless of undoubted under-reporting, some factors must be involved in the selection of those who develop such glomerulopathies. On the basis of experimental and clinical evidence, this review highlights the importance of parasitic species, associated salmonellosis, genetic predisposition and impaired hepatic macrophage activity. It also discusses the potential pathogenic role of the prevailing parasite 'strains', intensity of infestation, associated infections with hepatitis B, and common urinary pathogens and impairment of hepatocellular function. Selection ultimately seems to be multifactorial, but there is evidence that inefficiency of the hepatic macrophage system plays a key role by allowing both schistosomal antigens and IgA polymers to escape hepatic clearance and/or modulation.
Nephrol Dial Transplant 1987
PMID:Schistosomal glomerulopathy: selection factors. 312 49

Chronic peritoneal dialysis (PD) is a common dialysis treatment modality used to treat children with end-stage renal disease. Dialysis-related infections are the leading cause of technique failure. Enterobius vermicularis infestation indirectly increases the infection rate by causing pruritus around the anus, especially at night. We observed a significant decrease in the total infection rate (2.3 vs 5.4 per patient-year) following regular deworming over a 1-year study period. Regular deworming may be considered to prevent secondary bacterial infections in children on chronic PD.
Perit Dial Int
PMID:Regular Deworming: A Missed Opportunity to Prevent Peritoneal Dialysis-Related Infections in Children. 2700 38