Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Guinea-pig developed resistance to Dermacentor andersoni larvae after one infestation. Cyclophosphamide administered in one dose (300 mg/kg) 48 hr prior to an initial infestation with larvae blocked the acquisition of resistance. When cyclophosphamide was given in a similar regimen to guinea-pigs which had already acquired resistance, the expressin of resistance was partially blocked. It was proposed that the blockage of the acquisition of resistance further confirmed the immunological nature of tick resistance. Partial blockage of the expression of resistance by cyclophosphamide substantiated the presence of a humoral component to the resistance mechanism. The presence of a cell-mediated component was previously well established.
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PMID:Acquired resistance to ticks. II. Effects of Cyclophosphamide on resistance. 127 85

Parenteral administration of cyclophosphamide in rabbits made resistant to infestation by the tick Rhipicephalus appendiculatus, resulted in abrogation of the resistance phenomenon. As a result, a high percentage (83%) of the larval ticks fed to repletion. This was in contrast to the control rabbits which were expressing the phenomenon of resistance to infestation by the ticks. In the latter, only 28% of the ticks fed to repletion. Cyclophosphamide administration in rabbits induced a leucopenia and depressed antibody response to the heterologous antigen, sheep red-blood cells.
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PMID:Effect of cyclophosphamide on the acquisition of resistance to infestation by Rhipicephalus appendiculatus in rabbits. 884 6