Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recurrent skin edemata due to an infestation with the filaria Loa loa are called Cameroon or Calabar swellings. These are tense elastic, circumscribed, indolent swellings, which are just slightly red coloured and disappear within 24 to 48 hours. Intervals of several weeks or months may occur. One should think of Loa loa disease seeing travellers return from Loa endemic areas (West Africa) with recurrent, transitory edema and eosinophilia. The stay in these areas may have been several years before! Treatment and prophylaxis: Diethylcarbamazine.
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PMID:[Cameroon swelling; infection by the filaria Loa loa]. 29 83

Young people constitute 46% of the population in the West Bank of Israel and 48% in the Gaza Strip with a rate of growth of 3.1% and 3.4%, respectively. Their living conditions are characterized by lack of sanitation, shortage of water (especially in comparison to Israel proper), unemployment, curfews and closing of schools during tense periods by the military authorities as collective punishment for incidents. Since 1967, Israel has controlled and administered the health care service in these territories. Since the 1980s dilution of pediatric care has been documented in the West Bank: there were no special services available for treating 200 Palestinian children with malignant tumors. Decentralization has resulted in only 1 project around Hebron and in 10 villages in the vicinity of Jerico when the objective was to reach by community-based service 200 villages in want of out patient child and maternal health services. Official Israeli sources indicated a greatly reduced infant mortality by 1987; to below 30/1000, but other sources indicated 91/1000 live births under 1 year of age and 120/1000 under 3 years of age. These rates are contrasted with 18/1000 among the Palestinian community in Israel and 12/1000 among the Hebrew population itself. Infant mortality and morbidity is caused by diarrheal and respiratory diseases. A high incidence of dental caries and dermatological and intestinal parasitological problems have also been encountered by an Italian medical team. In 3 villages studied there was a 32% incidence of intestinal parasitic infection in children up to 3 years of age; 26% giardia lamblia, 3% entamoeba histolytica, 3% hymenolepis nana, 3% entamoeba coli, and 1% ascaris lumbricoides. 3% had double infestation. In 1990 the UN registered 329 cases of measles: 252 in Syria, 45 in Lebanon, and 122 in Gaza. 153 of these had been vaccinated, and in Gaza there had been a measles vaccination campaign. The incidence of diseases dependent on the environment have decreased: infantile diarrhea, infectious hepatitis, and intestinal fever. The problems of public health can only be resolved by an independent national authority.
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PMID:[The living and health conditions of Palestinian children]. 129 73

A previously unreported form of localized bullous scabies mimicking bullous pemphigoid is described. The patient presented with a localized, severely pruritic erythematous plaque with a cutaneous eruption consisting of several papules and a single tense bulla on an erythematous base. The histologic findings consisted of a subepidermal inflammatory bullous dermatosis with lymphocytes, neutrophils, and many eosinophils, and the results of direct immunofluorescence were negative. Correlation of the clinical course with the histologic and immunofluorescence findings were necessary to establish the diagnosis of infestation by Sarcoptes scabiei.
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PMID:Localized bullous scabies. Uncommon presentation of scabies. 831 Nov 94

Two patients were admitted to our hospital with tense blisters on an erythematous base, typical for bullous pemphigoid. In both patients an infestation with Sarcoptes scabiei was diagnosed by dermatoscopy as well as histological examination. In one patient the clinical diagnosis of bullous pemphigoid could be confirmed by immunofluorescence microscopy, histopathology and a clinical relapse of bullous pemphigoid without scabies infestation. In the other patient no evidence for an autoantibody-mediated autoimmune blistering disease was found. We postulate that bullous scabies could develop after long persistency of the parasites leading to a specific immune response with activation of T helper type 2 (Th2) cells causing high levels of the cytokine interleukin 5 and then consecutively eosinophilia. Secretion of proteolytic enzymes near the basal membrane zone might explain the development of intraepidermal, often suprabasal blisters. In contrast, in the first patient the scabies infestation might have triggered a flare up of the underlying autoimmune disease. Comparison of our two patients demonstrates two entities: bullous pemphigoid triggered by scabies as a Koebner phenomenon and a bullous subtype of scabies mimicking bullous pemphigoid. Therefore both, scabies infestation triggering bullous pemphigoid and bullous pemphigoid-like scabies should be included in the differential diagnosis of vesicles, tense blisters and erythema, especially at an early clinical stage.
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PMID:[Bullous scabies and scabies-triggered bullous pemphigoid]. 1122 Feb 41