Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851341 (infestation)
10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The most common form of lower airway disease (LAD) in dogs is chronic bronchitis, whereas in cats a syndrome resembling chronic bronchial asthma in humans is commonly reported. In most cases, the cause(s) of LAD remains unproven. The primary symptom of LAD in dogs and cats is chronic cough, although many cats are free of symptoms between episodes of acute, life-threatening bronchoconstriction. Diagnosis is based on a careful history, physical examination, and diagnostic tests designed to rule out other causes of cough and dyspnea such as pneumonia, heartworm infestation, and congestive heart failure. More sophisticated tests, such as bronchoscopy, flow volume loops, and radioisotope ventilation scans are available to define the extent of the disease process better. Glucocorticoids remain the mainstay of chronic therapy for most dogs and cats with LAD. Bronchodilators are indicated for most cats with symptoms of acute bronchoconstriction, whereas a smaller number of dogs may respond to bronchodilator administration and demonstrate an increase in exercise capacity and a decrease in cough frequency. LAD in dogs and cats is a progressive disorder, and prognosis is guarded. Nevertheless, with aggressive medical management many of these animals can live relatively symptom-free lives.
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PMID:Chronic lower airway disease in the dog and cat. 164 17

Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physicians with signs and symptoms of this disorder. Clinical manifestations included chronic cough for up to two years, apparent hemoptysis in two patients, lack of fever or sweats, and family history negative for tuberculosis. Physical findings included rales and dullness to percussion, clubbing (one patient), and lack of fever or respiratory distress. All three patients showed interstitial infiltrates on chest roentgenogram whereas two had multiple small cystic areas. Moderate eosinophilia was present. Paragonimus westermani ova were found in stools of two patients, in sputum of two patients, and in bronchoscopic specimens in one patient. All patients demonstrated striking clinical and radiologic improvement following treatment with bithionol (50 mg/kg every other day for 15 doses), which was well tolerated. Lung fluke infestation must be considered in Indochinese refugee children with apparent hemoptysis or chronic pulmonary symptoms, and sputum and stool should be examined for P westermani ova.
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PMID:Pulmonary paragonimiasis in Laotian refugee children. 709 90