Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0851341 (
infestation
)
10,121
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two ruminant acute phase proteins (APPs), haptoglobin (Hp) and
serum amyloid A
(
SAA
), were evaluated as serum biomarkers (BMs) for sheep scab-a highly contagious ectoparasitic disease caused by the mite Psoroptes ovis, which is a major welfare and production threat worldwide. The levels of both APPs increased in serum following experimental
infestation
of sheep with P. ovis, becoming statistically significantly elevated from pre-
infestation
levels at 4 weeks post-
infestation
. Following successful treatment of infested sheep with an endectocide, Hp and
SAA
serum levels declined rapidly, with half lives of less than 3 days. In contrast, serum IgG levels which specifically bound the P. ovis-derived diagnostic antigen Pso o 2 had a half-life of 56 days. Taking into account pre-
infestation
serum levels, rapidity of response to
infestation
and test sensitivity at the estimated optimum cut-off values,
SAA
was the more discriminatory marker. These studies illustrated the potential of
SAA
and Hp to indicate current sheep scab
infestation
status and to augment the existing Pso o 2 serological assay to give disease-specific indications of both
infestation
and successful treatment.
...
PMID:Two major ruminant acute phase proteins, haptoglobin and serum amyloid A, as serum biomarkers during active sheep scab infestation. 2417 40
