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Query: UMLS:C0851341 (infestation)
 10,121 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty consecutive cases of portal hypertension seen in a surgical unit in Lusaka, Zambia, are reported. Of these cases 70% were due to portal fibrosis caused by Schistosoma mansoni infestation. Portacaval shunting was undertaken in most cases. Patients with portal fibrosis responded more favourably to portal decompression than did patients with cirrhosis. It is probable that the condition is more common than is generally reconigzed in areas where S. mansoni infestation is endemic.
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PMID:Bilharzial portal fibrosis: an important cause of portal hypertension. 62 72

This is a review article concerning the surgical aspects of parasitic disease in childhood. The surgeon encounters parasitic disease for a variety of reasons. Many forms of infestation produce or mimic anatomic diseases of the gastrointestinal tract. Others are characterized by soft tissue or visceral mass lesions, lymphadenopathy, portal hypertension, etc. The surgical aspects of parasitism extend to all subspecialties, including ophthalmology, gynecology, and plastic surgery.
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PMID:Surgical aspects of parasitic disease in childhood. 355 27

Pathological and hemodynamic investigations were performed in 5 canadian patients who had been infected by Schistosoma mansoni four months before in Martinique. Mononuclear cell infiltration of portal tracts was disclosed in all 5 patients; it was associated with eosinophilic infiltration in 3, hepatocellular necrosis in 3, granulomas in 2 and fibrosis in 2. Presinusoidal portal hypertension was demonstrated in 4 out of the 5 patients. These observations suggest that histological changes are constant at this stage after infestation by S. mansoni and could be responsible for the early development of portal hypertension which is classically a late feature of the disease.
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PMID:[Intestinal schistosomiasis. Early hepatic involvement with portal hypertension: study of 5 cases]. 687 82

Schistosoma mansoni schistosomiasis is widespread in Latin America and Black Africa. Infestation is through the skin where it produces erythema with pruritus. Invasion is manifested by mild or sometimes fairly marked systemic disorders. The gastrointestinal disorders observed in the established phase have no characteristic features. The major complication is portal hypertension due to the portal vein fibrosis provoked by schistosomatic granules with an egg at their centre. The diagnosis rests on the finding of eggs in the faeces and on biopsy of the rectal mucosa. The present treatments are effective and well tolerated, but a portocaval anastomosis may be necessary.
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PMID:[Symptoms and development of Schistosoma mansoni infestation]. 834 4

The authors present marsh rat Holochilus brasiliensis, jirds Meriones shawi and M. unguiculatus as new models of Schistosoma haematobium infection. Histological findings were compared with those of classic models mouse Mus and hamster Mesocricetus. In new models, embryonated eggs were seen in the stool from 90 days post infestation (DPI) and active disease developed from 117 to 175 DPI. Seven out of 10 rodents presented granulomatous and/or chronic cystitis, fibrosis, polyps and urothelial changes: squamous metaplasia, precancerous dysplasia and squamous cell carcinoma of the urinary bladder. In the digestive tract of all new models, granulomas eroded the mucosa, formed inflammatory polyps, infiltrated the wall and accumulated into bilharziomas. In the liver, granulomatous hepatitis surrounded by bilharzial pigment deposit was apparent. Pipe-stem fibrosis involved 4 rodents with precirrhotic changes in 1 and portal hypertension in 2. One female Meriones suffered from granulomatous endometritis and salpingitis. All new models developed pulmonary granulomatosis with associated vascular lesions: giant cell arteritis in 1 rodent, thromboses in 3 and pulmonary hypertension in 4 others. In classic models, 1 Mus presented a squamous cell carcinoma of the urinary bladder while Mesocricetus displayed diverse lesions in digestive and genital tracts, liver and lungs. All tissue lesions, resembling those seen in humans in all points, were far more frequent and severe in new models than in classic ones. Those involving the urinary bladder have never been reported in other models such as monkeys: Pan troglodytes, Cercopithecus aethiops and Cebus apella. A comparison was carried out between different models on the basis of experimental conditions: definitive hosts, number of cercariae used, type and duration of infection. This study clearly demonstrated that Holochilus brasiliensis, Meriones shawi and M. unguiculatus are perfectly adequate models in terms of laboratory facilities. They are helpful in investigating the pathogenic mechanism of some disorders in S. haematobium infection, particularly tumours of the urinary bladder, and this may enhance therapeutic assays.
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PMID:Histopathological observations in new and classic models of experimental Schistosoma haematobium infections. 867 38

Abdominal ultrasound is a reliable and reproducible technique for monitoring the progression of hepatosplenic schistomiasis. It was used in the framework of the @Hope" program against endemic Schistosoma mansoni in the Senegal River region. A total of 166 patients presenting Schistosoma mansoni eggs in stools were divided into age groups with a sex ratio of 1. All patients underwent the same ultrasound examination including measurement of the liver and assessment of the branches of the portal vein system. Our findings indicated that highly sensitive hypertrophy of the left lobe of the liver occurs early since this feature was observed in all patients over the age of 15 years. Alterations of the portal system were observed in 73% of patients but were moderate, stage 1, in the zone where incidence of positive stools is over 90%. Grade III lesions were only found in patients over 23 years of age. Although these lesions accounted for 4% of the cases, this finding underscores the need for surveillance in a region where infestation became endemic less then ten years ago raising fears that severe schistosomal portal hypertension would become widespread. A mobile ultrasonographic surveillance unit would be useful in the region.
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PMID:[Value of hepatosplenic ultrasonography in the surveillance of Schistosoma mansoni endemics (a study conducted in the Richard Toll region of Senegal)]. 902 95

Hookworm infestations, endemic in India, are a common cause of iron deficiency anemia. Hemosuccus pancreaticus, a rare clinical condition, is due to passage of blood into the pancreatic duct possibly through a route between an aneurysm of an artery close to the pancreas and/or pancreatic duct, leading to gastrointestinal (GI) bleeding. Portal hypertensive upper GI bleed is also known since long. We report a case of a 38-year-old male with a history of alcoholism who was being investigated for GI bleeding who had concomitant hookworm infestation, hemosuccus pancreaticus as well as portal hypertension. To the best of our knowledge, this is the first report of common occurrence of hemosuccus pancreaticus and portal hypertension with hookworm infection. This case signifies the importance of infectious causes of GI bleeding to be considered even in cases where anatomic malformations or pathophysiological alterations are predominant.
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PMID:Association of Three H - Hookworm, Hemosuccus Pancreaticus, and Hypertension (Portal) in a Patient with Melena. 2887 25