Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gly-Leu-Phe (GLF), an immunostimulating peptide derived from alpha-lactalbumin, prevented alopecia induced by an anticancer agent etoposide in a neonatal rat model after intraperitoneal injection at a dose of 100 mg/kg for 4 d or oral administration at a dose of 300 mg/kg for 6 d. By microscopic analysis of skin sections, GLF proved to inhibit etoposide-induced loss of hair, thickening of the epidermis, and thinning of the adipocyte layer. The anti-alopecia effect of GLF was inhibited by pyrilamine, a histamine H1 receptor antagonist, suggesting that the anti-alopecia effect is mediated by histamine release.
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PMID:Anti-alopecia effect of Gly-Leu-Phe, an immunostimulating peptide derived from alpha-lactalbumin. 1611

Onychomycosis is the most common nail disease. There are various treatments available, the majority of which are topical and systemic therapies. However, the poor nail penetration, systemic side effects and the poor compliance of the patients lead to limited efficacy. Photodynamic therapy may be an option. Yet, the penetration of photosensitizer into the nail plate needs to be improved. Here, we report a case of onychomycosis successfully treated with 20 % 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). Toenail thinning with a common nail file was given before PDT. This suggest that thinning toenails, combining with topical ALA-PDT may be an effective, feasible, and safe alternative for the treatment of onychomycosis, especially for cases recalcitrant or inappropriate to other conventional therapies.
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PMID:Combination of toenail thinning and photodynamic therapy in distal and lateral subungual onychomycosis treatment: A case report. 3210 22