Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Defibrotide is an antithrombotic and profibrinolytic drug which modulates endothelial function. The drug increases prostacyclin and tissue plasminogen activator while it decreases plasminogen activator inhibitor synthesis by endothelial cells. In this study, in vivo effects of defibrotide on the morphology of endothelial cells and vessel wall of the healthy rabbits were investigated by light and electron microscopy. The examination of the carotid arteries of healthy rabbits after infusion of saline or defibrotide (10 mg/kg/hr) in saline solution for three hours revealed that the drug had induced dramatic morphological changes in all the test animals while no change was observed in control group. The changes observed after defibrotide administration, such as the decrease in hill and valley-like appearance of endothelial surface, and thinning of the intimal layer provides evidence for the vasorelaxant effect of the drug, while the decrease in the number of blood cells adhering to the endothelial surface confirms the antithrombotic effect of defibrotide. Finally the decrease in the number of crater-like structures may be due to the cytoprotective effect of the drug.
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PMID:Morphological changes in carotid arteries of rabbits induced by defibrotide infusion. 790 91

Myopic submacular hemorrhage (SMH) usually arises from either a break in Bruch's membrane (lacquer cracks) that damages the underlying choriocapillaris or the development of a choroidal neovascular membrane (CNVM) at the sites of prior lacquer cracks.1,2 In pathologic myopia (PM), axial elongation leads to thinning of the choroid and retinal pigment epithelium, predisposing to rupture of Bruch's membrane.3 If large hemorrhages involving the fovea are left untreated, subretinal hemorrhage and CNVM can cause devastating long-term vision loss due to irreversible retinal atrophy.4 In this video, the authors describe their technique of using a subretinal injection of recombinant tissue plasminogen activator with a concurrent gas tamponade to displace SMH.
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PMID:Displacement of Submacular Hemorrhage With Subretinal Injection of Recombinant Tissue Plasminogen Activator and Gas Tamponade in the Setting of Myopic Degeneration. 3099 50