Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three patients who had a diagnosis of congenitally absent lumbar pedicle underwent CT examination. Findings showed that each patient had an aberrant hypoplastic pedicle plus a retroisthmic defect in the ipsilateral lamina rather than an absent pedicle. Axial CT was the diagnostic modality of choice; reformated images were of little value. The nature of the anomaly explains the difficulty in diagnosis by plain film radiography or tomographic study. The differential diagnosis to be considered from findings of plain film radiography includes pediculate thinning, neoplastic disease, neurofibroma, mesodermal dysplasia associated with neurofibromatosis, and vascular anomalies.
Radiology 1984 Sep
PMID:Congenitally absent lumbar pedicle: a reappraisal. 646 53

These investigators have previously developed a model for inducing aortic aneurysms by administering theophylline or caffeine to embryonic chicks. This report describes light-microscopic and ultrastructural changes in aortic walls of theophylline-treated embryos relative to saline-treated controls. Light-microscopic examination of areas of permanent aortic dilatation revealed thinning of the medial layer due to a marked decrease in the number of medial cells. Electron-microscopic observation of aortic walls with aneurysms revealed widely scattered medial cells with scanty cytoplasm containing poorly developed microorganelles, a markedly widened intercellular space with dispersed elastic and collagen fibers in the tunica media, and a disruption of endothelial cells. It is suggested that the induction of aortic aneurysms by theophylline in chick embryos may be attributed to two factors: 1) atrophy and subsequent hypoplasia of the aortic media possibly resulting from an elevated intracellular cyclic adenosine 3',5'-monophosphate, which inhibits mitosis in medial cells, and 2) altered hemodynamics due to the action of theophylline on the embryonic heart.
Am J Pathol 1983 Sep
PMID:Light- and electron-microscopic observations of theophylline-induced aortic aneurysms in embryonic chicks. 661 41

Two patients with severe generalized psoriasis and psoriatic arthritis whose conditions had failed to respond to oral therapy with traditional remedies, including etretinate (both patients) and its combination with psoralen and UV-A (PUVA) (one patient) were successfully treated with minimal oral dosages of the arotinoid RO 13-6298 (0.05 to 0.1 mg/day). Side effects of this new synthetic retinoid included dryness of the lips and nasal mucosa, some palmarplantar desquamation, gross thinning of the skin, itching, and transient hair loss. Laboratory investigations disclosed no abnormalities attributable to the drug. The new arotinoid, RO 13-6298, seems to be a highly potent retinoid in its antipsoriatic effects. It represents the third generation of synthetic retinoids that may be effective in extremely low doses.
Arch Dermatol 1983 Sep
PMID:Antipsoriatic activity of a new synthetic retinoid. The arotinoid RO 13-6298. 661 62

Gross, light microscopic, and morphometric changes were observed in the small intestines of 11 neonatal gnotobiotic dogs after oral inoculation with a canine rotavirus. Starting in pups killed at postinoculation hour (PIH) 24, gross changes consisted of moderate dilatation and thinning of the walls of the small intestine, hyperemia, and a moderate amount of semiliquid-to-liquid greenish-yellow intestinal contents. In the jejunum and ileum of inoculated pups killed from PIH 18 to 48, columnar villus epithelial cells on the upper one-third of the villus were necrotic, and foci denude of epithelium were seen on the upper regions of villi. Inoculated pups killed from PIH 24 to 72 had mild-to-moderate villus atrophy in the jejunum and ileum, villi covered with cuboidal-to-flat squamous-like epithelial cells, and absence of large, clear vacuoles in the jejunal and ileal villus epithelial cells similar to those seen in villus epithelial cells of 9 control pups. Microscopic sections of the jejunum and ileum from inoculated pups killed from PIH 72 to 154 showed slight-to-moderate villus atrophy, and the villi were covered with cuboidal-to-low columnar epithelial cells. Morphometric results indicated lower mean villus-crypt ratios in the duodenum, jejunum, and ileum of inoculated pups. In addition, the morphometry of the small intestine indicated that crypt cell hyperplasia occurred in the duodenum early during infection without obvious villus atrophy, and hyperplasia of the crypt cells in the jejunum and ileum was observed later during the infection.
Am J Vet Res 1983 Sep
PMID:Gross and light microscopic lesions in neonatal gnotobiotic dogs inoculated with a canine rotavirus. 662 23

The real time two-dimensional ultrasonic imaging of the left ventricle made possible segmental echocardiographic measurements of wall motion and thickening and thinning. The underlying hypothesis is that measurements of regional wall motion could quantify the extent of myocardial ischemia and infarction; the method could be used as a truly non-invasive tool to assess the severity of damage from infarction and the effects of interventions designed to limit infarcts. The method is operator interactive. Each patient's data could be compared with data for a normal group. The selection criteria for the normal patients have been described. The confidence region of the normal group and the effect of averaging over three tracings for three heartbeats have been computed. Technical difficulties inherent in the method and possible improvements are discussed.
Int J Biomed Comput 1983 Sep
PMID:Quantitative analysis of left ventricular wall motion and thickness using two-dimensional echocardiography. 664 52

When fed furazolidone, 700 ppm, with their mash, most turkey poults develop dilated cardiomyopathy characterized by gross left ventricular dilatation with thinning of both the left ventricular free wall and ventricular septum. Birds fed propranolol, but not digoxin, did not develop this cardiomyopathy. It is not known what pharmacologic property of propranolol conferred protection or if mammals would receive similar protection.
Am J Cardiol 1983 Sep 01
PMID:Protection of turkeys against furazolidone-induced cardiomyopathy. 668 89

To determine if there is a quantitative relationship between systolic contraction abnormalities (demonstrated by two-dimensional echocardiography) and reduced myocardial perfusion in a setting of moderate and severe coronary stenosis, we created 70% or 90% reduction in circumflex coronary artery diameter in open-chest dogs. Transient ischemia was induced by superimposing increased myocardial oxygen requirements (i.v. isoproterenol, aortic constriction) in the presence of the stenosis or by decreased coronary perfusion (lowering arterial pressure with i.v. nitroprusside, nitroglycerin, or hemorrhage). Acute systolic wall thinning show by two-dimensional echocardiography or by implanted myocardial sonomicrometers was taken as functional evidence of myocardial ischemia. Myocardial perfusion was determined by radiolabeled microspheres when wall thinning was apparent. Systolic wall thinning could not be induced by these interventions when the degree of coronary stenosis was only 70%. Systolic wall thinning occurred only when increased myocardial oxygen requirements or decreased aortic pressure were superimposed on 90% coronary stenosis. Under these conditions, myocardial perfusion was reduced to 28 +/- 27 ml/100 g/min (mean +/- SD), 15--25% of control. Aortic diastolic pressure was a major determinant of ischemia in that contraction abnormalities produced by a 90% stenosis and vasodilators or hemorrhage could be acutely reversed by superimposing acute aortic constriction, which elevated arterial pressure; myocardial perfusion increased correspondingly. Thus, the demonstration of transient systolic wall thinning by two-dimensional echocardiography during a stressful intervention indicated that severe coronary stenosis was present, and that the perfusion of the acutely dyskinetic myocardial area was 25% of control or less.
Circulation 1982 Sep
PMID:Two-dimensional echocardiography in experimental coronary stenosis. II. Relationship between systolic wall thinning and regional myocardial perfusion in severe coronary stenosis. 680 69

The sonographic and computed tomographic features in a case of replacement lipomatosis of the kidney are presented, along with pathologic correlation. Computed tomography demonstrated a staghorn calculus and marked atrophy of the renal parenchyma, along with diffuse increase in renal sinus and perirenal fat. Sonography showed thinning of the renal parenchyma and high-amplitude echoes throughout the kidney, corresponding to the increase in renal sinus fat. The prospective diagnosis of replacement lipomatosis, and differentiation from other causes of nonfunction of the kidney due to staghorn calculus, can be readily made.
Radiology 1983 Sep
PMID:Replacement lipomatosis of the kidney: diagnosis by computed tomography and sonography. 687 3

The purpose of this study was to assess the sensitivity and specificity of two-dimensional echocardiography in detecting ischemia-induced transient myocardial dyskinesis. We prepared an open-chest dog model of severe coronary stenosis (90% reduction of circumflex coronary artery diameter) and induced ischemia by acutely raising myocardial oxygen requirements with i.v. isoproterenol and acute aortic constriction. The changes observed with echocardiography were compared with those obtained by intramyocardial sonomicrometers placed side by side or in an endocardial-epicardial orientation. Ischemia was defined as systolic wall expansion or thinning on sonomicrometers and two-dimensional echocardiography. We found complete agreement between sonomicrometers and two-dimensional echocardiography in all control tracings and after ischemia was induced; whenever dyskinesis occurred it was seen by both techniques. Although there was qualitative agreement between echocardiographic and sonomicrometric techniques, there were quantitative differences in the assessment of wall thickening. Such differences may be related to malalignment of the sonomicrometers, echocardiographic resolution limitations or other technical factors. We conclude that two-dimensional echocardiography is a sensitive and specific technique for detecting transient myocardial ischemia, and therefore should be useful for demonstrating exercise-induced ischemia in patients with coronary artery disease.
Circulation 1982 Sep
PMID:Two-dimensional echocardiography in experimental coronary stenosis. I. Sensitivity and specificity in detecting transient myocardial dyskinesis: comparison with sonomicrometers. 709 70

In patients with psoriasis, partial stripping of the stratum corneum induced minute erythematous and edematous, nonscaling papules six hours to seven days later. These "prepinpoint papules" PPPs) comparable to spontaneous PPPs, which we described earlier, appeared in 75 of 159 patients with active psoriasis but in none of 27 controls; 73% to 91% of these PPPs, depending on the activity of the disease, transformed into pinpoint papules. Histological and histochemical examinations of the PPPs showed infiltrates containing numerous polymorphonuclear leukocytes around the vessels and penetrating into the epidermis, partly destroying it. The earliest change in the epidermis was thinning of the granular layer without other features of psoriasis. Immunoglobulin G and complement deposits on stratum corneum (SC) antigen sites were found in the PPPs initially in about one third, and later in two thirds of the papules, whereas they were present in virtually all of the psoriatic pinpoint papules. Papules induced by stripping, similar to spontaneous PPPs, play a central role in the etiology of at least some forms of psoriasis. Polymorphonuclear leukocyte infiltrates and SC antibody binding are key features of the conversion of PPP to pinpoint psoriatic lesions.
Arch Dermatol 1982 Sep
PMID:Stripping of the stratum corneum in patients with psoriasis: production of prepinpoint papules and psoriatic lesions. 711 67


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>