Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Methyl n-butyl ketone (MBK) is known to produce a giant axonal neuropathy in man and experimental animals characterized pathologically by a gradual increase in the number of neurofilaments which become associated with focal areas of axonal swelling and thinning of the myelin sheath. Fast axoplasmic transport was studied in rats exposed to MBK. In 10 severely paralyzed rats exposed to MBK there was a significant impediment of fast axoplasmic transport following dorsal root ganglion injections (x +/- S.D. = 283.2 +/- 20.34 mm/day) compared to normal controls (417.6 +/- 23.78 mm/day). In rats undergoing injections into the ventral horn of the spinal cord there was a gradual impairment of the mean down flow rate for transport of [3H]leucine which correlated with the severity of the MBK induced neuropathy. Quantitative morphological determinations showed that the total number of neurotubules per unit cross-sectional myelin area and the number of neurotubules associated with mitochondria in swollen axons was unchanged from normal. The total number of mitochondria in randomly sampled axons varied significantly from controls but the absolute number of mitochondria associated with neurotubules was unchanged from normal. The results of these studies suggest that the impediment of fast axoplasmic transport may be related to the increased neurofilaments producing focal areas of axonal blockage.
Brain Res 1977 Sep 09
PMID:Alterations of fast axoplasmic transport in experimental methyl n-butyl ketone neuropathy. 7 Nov 85

Organochlorine and mercury concentrations are reported for 252 eggs of Leach's storm-petrel (Oceanodroma leucorhoa), double-crested cormorant (Phalarocorax auritus), common eider (Somateria mollissima), common tern (Sterna hirundo), razorbill (Alca torda), common murre (Uria aalge) black guillemot (Cepphus grylle), and Atlantic puffin (Fratercula arctica) from the Bay of Fundy, the Gulf of St. Lawrence, and the open Atlantic shore of Canada during 1970-76. Concentrations of all organochlorines except DDE and polychlorinated biphenyls (PCBs) were low. DDE, PCBs, and mercury residues were highest in cormorant and petrel, intermediated in alcids, and lowest in eider and tern. Temporal and spatial aspects of contamination patterns are discussed. Authors conclude that only in cormorants were DDE residues high enough to cause, through eggshell thinning, local population declines.
Pestic Monit J 1979 Sep
PMID:Shell thinning and residues of organochlorines and mercury in seabird eggs, Eastern Canada, 1970-76. 11 27

Ocular rosacea was diagnosed in 49 patients. The most common signs and symptoms were foreign body sensation, burning, superficial punctate erosions, chalazia, and belpharitis. Less common but dangerous to the vision was corneal thinning, vascularization, and infiltrates. Three new associated symptoms were found. These were mapdot subepithelial opacities, recurrent erosions, and moderately severe foreign body sensation, pain or burning with minimal associated signs. Of the 49 patients, 37 were treated with 250 mg of oral tetracycline four times a day, which resulted in improvement in almost all patients from four to 17 days after initiation of therapy. Most of the patients have been able to taper, or taper and stop therapy without recurrence of their symptoms. Those patients with foreign body sensation, burning, and pain required the most prolonged therapy in order to taper or stop treatment with tetracycline.
Am J Ophthalmol 1979 Sep
PMID:Ocular rosacea. 15 14

The effect of subinhibitory concentrations of monomycin on the submicroscopic structures of 2 strains of S. typhi, 5 and 799 was studied. It was shown that formation of filamentoue forms, separation of the cell wall, thinning out of the cytoplasm granular component, increasing of the size of the matter with low electron optic density of fine granular structure were common in the cell response of both strains. Formation of vacuoli containing the thinned out granular component, filterable elements and complex membrane structures followed by their liberation into the medium and formation of the forms devoid of the cell walls was a characteristic peculiar property of the cell response in strain 799. The cells of strain 5 were characterized by formation of large granular osmiefilic matters and their excretion from the cells.
Antibiotiki 1976 Sep
PMID:[Effect of antibiotic action on the submicroscopic structure of Salmonella. The action of monomycin on S. typhi]. 18 11

Twenty-four maxillary anterior composite restorations from a clinical study of resin coating were examined at the time of baseline evaluation and at 23 months; electroplated positive replicas, impression negative replicas, and SEMs were used for evaluation. Coated restorations had smooth surfaces after 23 months, in comparison with rough surfaces of uncoated restorations. Defects in some of the resin coatings were found at the time of baseline evaluation; these included isolated areas of the composite or etched enamel that were not covered by the resin. Later examinations showed cracking of part of the edges of resin coating, development of bare areas, thinning of the coating edges, or generalized loss of the protective coating. The defects seen immediately after placement of the coatings were probably caused by errors in technique that include: application of the resin in a layer that was too thin; surface contaminants in the area of application; moisture on the surface of the composite or enamel; and areas of inadequate enamel etching were adjacent to the cavosurface margin of the composite. The appearance of bare spots or total loss or thinning of the resin coating edges during the later examinations is caused by wearing or abrading of the resin coatings from natural or mechanical causes. This seems to be a function of the initial coating thickness and its location on the tooth.
J Am Dent Assoc 1978 Sep
PMID:Surface characteristics of resin-coated composite restorations. 27 1

Anthracene with near ultraviolet (UV) light (UVA, 320--400 nm) has been shown previously to inhibit epidermal deoxyribonucleic acid (DNA) synthesis and mitosis. This suggested that the combination of anthracene and UVA light could suppress the rapidly proliferating epidermis of psoriasis. In this preliminary clinical study, anthracene plus UVA light improved psoriasis as shown by thinning of plaques and decreased scale in four of five patients, with complete or almost complete clearing in two of these four patients. These findings indicate that anthracene with UVA light might be helpful in the control of psoriasis.
J Am Acad Dermatol 1979 Sep
PMID:Psoriasis improved by anthracene with near ultraviolet light. 51 76

The effect of stenosis of the left main and proximal anterior descending coronary arteries on anterior left ventricular wall dynamics was investigated in 70 patients with ischemic heart disease by the use of roentgen videometric analysis of left ventricular angiograms. In all patients with ischemic heart disease, mean values for peak rate of systolic wall thickening and diastolic wall thinning were significantly smaller than normal (P less than 0.01). In patients without infarction, there was no correlation between peak rate of systolic anterior wall thickening and stenosis of the coronary artery supplying it, but there was a significant reduction in peak rate of diastolic wall thinning (P less than 0.01) in patients with stenosis greater than 90%; this difference was not apparent at any lower degree of stenosis. This population could not be recognized by any other parameter of global or regional ventricular function; thus, diastole is more sensitive to regional left ventricular dysfunction than systole.
Circulation 1978 Sep
PMID:Relation between left coronary artery stenosis and regional left ventricular function. 67 40

Progressive hemifacial atrophy is an unusual craniofacial deformity that is amenable to surgical reconstruction. The disease may involve any layer of the superficial facial tissues as well as cartilage and bone. While the cause of the disease is unknown, several hypotheses exist to account for the progressive nature of the disorder. Histologically, the skin undergoes thinning of the Malpighian stratum and atrophy of the skin adenexa and dermal units. The subcutaneous tissue shows chronic inflammatory changes. This picture closely resembles that of scleroderma, and some authors believe the disorder to be an isolated form of scleroderma. Various hypotheses have been promulgated as to the cause of this disorder, its pathologic process, and varied clinical presentation.
Arch Otolaryngol 1978 Sep
PMID:Hemifacial atrophy. A review of an unusual craniofacial deformity with a report of a case. 68 22

Gel formulations containing 2% pilocarpine hydrochloride were prepared from ethylene maleic anhydride, carbomer, hydroxyethylcellulose, polyacrylamide, ethylhydroxyethylcellulose, hydroxypropylcellulose, and poly(methylvinyl ether--maleic anhydride). The viscosity characteristics of each formulation were evaluated from rheograms developed at 37 degrees using a cone and plate viscometer. Single-point viscosities were determined at room temperature using a single-point rotational viscometer. Plastic viscosity parameters correlated to miosis durations in the rabbit following ophthalmic dosing of 50 microliters. Carbomer formulations varying in concentration between 0.9 and 5.0% (w/w) showed a discontinuous relationship when either yield value or plastic viscosity was plotted against miosis durations. At carbomer concentrations above 3%, miosis durations increased 1.5-fold. Above and below this range, plastic parameters did not correlate to miosis duration. It was reasoned that the increased duration was a consequence of the gel's increased yield value such that appreciable in vivo thinning of the gel does not take place with eyelid and/or eyeball movements. As a result, the residence time of the drug in the eye would be expected to increase, thus promoting an increased duration.
J Pharm Sci 1978 Sep
PMID:Inlfuence of high-viscosity vehicles on miotic effect of pilocarpine. 69 Aug 34

An Afrikaner kindred in South Africa had a dominantly inherited skeletal dysplasia-blindness-deafness syndrome. The affected individuals had reduced stature and a round, flattened facies. The bone changes resembled multiple epiphyseal dysplasia with additional minor abnormalities in the phalanges, femoral heads and spine. Progressive myopia, retinal thinning and crenated cataracts led to visual disturbance, while conductive deafness represented the third component of the triad. The syndromic significance of associated asteroid hyalosis is uncertain.
Clin Genet 1978 Sep
PMID:Dominant inheritance of multiple epiphyseal dysplasia, myopia and deafness. 69 54


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