Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The morphological appearance and quantitative parameters characterizing the dendrites of NADPH-diaphorase-stained neurons in the laterodorsal (LDT) and pedunculopontine (PPN) tegmental nuclei of 3-, 12- and 26-month-old rats were studied. All dendritic segments were classified according to the number of terminal and link segments they drain and the vertex analysis was used to quantify the dendritic tree and to determine its configuration. Morphological aberrations of the dendrites as local swelling, nodulation, thinning, shrinkage, folding and even the appearance of stumps were observed with advancing age. The quantitative analysis demonstrated a significant reduction (one-way ANOVA) of the total dendritic length, mean terminal path length, maximal segment length, total segment number and number of terminal segments at the rostral two thirds of the LDT and in the PPN. The mean vertex path length and the mean segment length significantly decreased only at the rostral level of the LDT. Plotting of the segment length against equivalent orders showed a decrease in all generations of the dendritic segments. The vertex ratios remained constant and indicated that the configuration of the dendritic tree remained unchanged during aging. The alterations in the dendrites mainly developed after 12 months of age. The age-related changes in the morphology and quantitative parameters of the dendrites in the rostral two thirds of the LDT and PPN were rather similar, which could be explained by the common anatomical, neurochemical and electrophysiological features. Thus, the present results suggest a mild, but continuous regression of the dendritic tree of the rat LDT and PPN in normal aging.
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PMID:Aging and the dendritic morphology of the rat laterodorsal and pedunculopontine tegmental nuclei. 923 33

Two common non-steroidal anti-inflammatory drugs (NSAIDs) and their nitric oxide (NO) adducts were evaluated for effects on stomach and thymus. Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1.33 x 10(-4)mol/kg of ibuprofen caused significant visual irritation score and microscopic thinning, although an ulceration assay proved insensitive. Ibuprofen esterified with NO abolished irritation and significantly reduced thinning. Gastro-protective effects of NO-linked ibuprofen were associated with higher levels of diaphorase by optical density, an enzymatic marker of local synthesis of nitric oxide. Both indomethacin and its congener at 2 x 10(-5)mol/kg produced microscopic signs of thinning only, not visible irritation or alteration of diaphorase staining. Results suggest that NO-linked ibuprofen can promote resistance to mucosal injury, possibly via local synthesis of NO. All NO-congeners and parent NSAIDs produced comparable reductions in the abundance of medullary nitrergic cells, those synthesising NO in thymus, without significantly lowering T-cellularity, the relative size of cortex wherein T-cells are produced. Findings indicate disturbance of T-cell tolerance, consistent with increased risk of autoimmune susceptibility.
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PMID:Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin. 1601 70