Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A randomized controlled trial of 160 patients undergoing endometrial laser ablation (ELA) was performed. Patients selected for ELA were randomized to receive either danazol or the GnRH analog Zoladex. Eighty patients were allocated to each group. Each group was also randomized to receive either 1 or 2 months of treatment prior to surgery The major end points for the study were patient compliance and drug-related side-effects, operative time and complications, effectiveness of endometrial thinning as judged by ultrasound, histologic measurements, and clinical response at 6 months assessment. Significant differences in the effectiveness of the two preparations were noted.
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PMID:A Prospective Randomized Trial Comparing a GnRH Analog, Zoladex, and Danazol as Agents for Priming the Endometrium Prior to Endometrial Laser Ablation 907 99

Our objective was to evaluate the effect of endometrial thinning by GnRH agonists on the results of hysteroscopic endometrial electrosurgical resection. In a prospective study, 32 women were treated with the GnRH agonist goserelin (Zoladex) before hysteroscopic endometrial resection. Endometrial thickness was measured before and after GnRH-a therapy by ultrasound. Short-term results in diminished vaginal blood loss and patient satisfaction were registered. The mean endometrial thickness (ET) before GnRH-a is 3.7 mm and after GnRH-a is 1.9 mm. In 24 cases, ET was reduced by a mean of 2.6 mm, in 1 case, no change was seen, and in 7 cases, ET increased by a mean 1.1 mm. The mean thickness rate (TR = ET before and after GnRH) is 2.7 (range 0.3-11). Fluid resorption during hysteroscopic surgery does not relate to ET or TR. Although the ET after GnRH-a therapy is not related to success or failure of the endometrial resection, there is some evidence that the TR is, probably expressing a more active state of the endometrium. Endometrial thinning by GnRH-a may have an effect on the results of hysteroscopic endometrial resection. In light of the present study and the literature, there seems to be no justification for abandoning preparation of the endometrium before hysteroscopic surgery.
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PMID:Endometrial electrosurgical resection by hysteroscopy in 32 menorrhagic patients: endometrial preparation with a GnRH agonist may have some effect on results. 1015 Jun 56