Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article describes a long-term, multicenter, open-label, 12-month study of once-daily fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05% (Tri-Luma Cream, hereinafter called TC [triple combination]) application in the treatment of melasma. A total of 228 patients with facial melasma were enrolled and treated; 173 patients (76%) completed the study. Most patients had 1 to 2 courses of treatment lasting approximately 6 months in total. TC cream showed a favorable safety profile. only 3 patients (1%) withdrew from the study due to treatment-related adverse events (AEs). A total of 129 patients (57%) experienced at least one treatment-related AE. Most AEs were expected application-site reactions that were mild and transient in nature and did not require remedial therapy. There were no cases of skin atrophy or skin thinning and only 6 cases of telangiectasia (5 mild and 1 moderate), most of which had improved by the end of the study. Results of the efficacy assessments were positive, with both the patient and the physician assessing melasma to be either completely or nearly cleared by the end of the study in more than 90% of cases. In this study, a once-daily application of TC cream over an extended period of 12 months showed no notable safety concerns and offered an effective treatment for melasma.
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PMID:Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma. 1573 37

In contrast to youthful skin, mature skin undergoes well-established clinical and microscopic changes, particularly after menopause. In particular, dermal thinning, loss of dermal collagen and decreased lipid production are complicated by the effects of life-long sun exposure. These changes manifest as wrinkling, loss of elasticity, dryness and textural changes that characterize mature skin. To effectively combat these age- and sun-related changes, a multifaceted approach is required. Any treatment for mature skin must address the many causes of skin changes, that is, collagen production, lipid balance and epidermal texture. Several currently available compounds have scientifically-established effects on skin, and are anticipated to be even more effective in combination. Women worldwide struggle with coming to terms with their aging skin, and seek ways to preserve its youthful appearance. While dermatologists' offices may offer tretinoin cream (Renova and related products), laser resurfacing approaches, volume fillers and Botox, demand also exists for topical products that preserve and improve skin tone. With the push toward "natural," "organic" and "herbal" products, public and private research has never generated more evidence for complementary therapy. During skin aging, and particularly menopause, characteristic changes occur. Topical compounds can target many aspects of the aging process. The following is a review of topical compounds that may help with particular parts of this process. How can different problems be approached? In addition to prescription approaches and physical modalities, several topical compounds, many available over the counter, show evidence for helping aged and photo-damaged skin. Clinical data exist for many of these compounds, and is divided by mechanism of action.
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PMID:Beyond tretinoin: cosmeceuticals for aging skin. 1958 45