Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The ultrastructure of skeletal muscle and activity of some enzymes of energy metabolism were studied to assess the effect of a deficiency of dietary energy and subsequent nutritional rehabilitation in 24 young, growing, healthy rhesus monkeys. Electron microscopy of muscles on energy-deficient animals showed thinning of myofibrils with widening of interfibrillar space and enlargement and accumulation of mitochondria at subsarcolemmal level. There was an apparent significant reduction in the fiber size. Muscle samples from each animal were analyzed for enzymes representative of glycolysis (phosphofructokinase [PFK] and lactate dehydrogenase [LDH], citric-acid cycle (isocitric dehydrogenase [ICDH] and citrate synthase [CS] and regeneration of ATP (creatine kinase [CK]. PFK and LDH activities were significantly augmented in energy-deficient animals. The increase in LDH activity resulted from a large increase in MU (skeletal muscle) LDH subunit. The activities of CS and ICDH were reduced. No alteration of CK in muscle and serum was observed. The morphological structure and enzyme activities returned to normal after nutritional rehabilitation.
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PMID:Ultrastructure and activity of some enzymes of energy metabolism of skeletal muscle in experimental energy deficiency. 310 25

We determined the effects of subsoiling on woody lateral roots and enzyme activities involved in stem carbon metabolism of 90- to 100-year-old Jeffrey pine (Pinus jeffreyi Grev. and Balf.) growing on the eastern side of the California Sierra Nevada Range. Twelve 1.0-ha plots were established on each of two sites. Four site treatments-thinning and subsoiling entire plots, thinning and no subsoiling, thinning and subsoiling skid trails only, and no thinning or subsoiling (undisturbed control)-were replicated three times on each site. Root excavations and assays of stem cambium sucrose metabolizing enzymes were carried out during the summer and fall of 1994 and 1995. Subsoiled plots had more roots < 1 cm in diameter exhibiting dieback than undisturbed plots. No relationship was found for stem cambial sucrose synthase (SS) activity among treatments or sites; however, a strong seasonal pattern was observed. Activity of pyrophosphate-dependent phosphofructokinase (PPi-PFK) was seasonal, whereas ATP-dependent phosphofructokinase (ATP-PFK) activity was constant throughout the seasons. Neither of the PFK activities responded to treatment or site. Among plots, ergosterol, a surrogate for estimating live fungal biomass, was present in highest concentrations in soil and rhizosphere samples from subsoiled plots.
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PMID:Effects of subsoiling on lateral roots, sucrose metabolizing enzymes, and soil ergosterol in two Jeffrey pine stands. 1487 95