Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Drug
Enzyme
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Query: UMLS:C0851184 (
thinning
)
11,252
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
TLX
is an orphan nuclear receptor that is expressed exclusively in vertebrate forebrains. Although
TLX
is known to be expressed in embryonic brains, the mechanism by which it influences neural development remains largely unknown. We show here that
TLX
is expressed specifically in periventricular neural stem cells in embryonic brains. Significant
thinning
of neocortex was observed in embryonic d 14.5
TLX
-null brains with reduced nestin labeling and decreased cell proliferation in the germinal zone. Cell cycle analysis revealed both prolonged cell cycles and increased cell cycle exit in
TLX
-null embryonic brains. Increased expression of a cyclin-dependent kinase inhibitor p21 and decreased expression of cyclin D1 provide a molecular basis for the deficiency of cell cycle progression in embryonic brains of
TLX
-null mice. Furthermore, transient knockdown of
TLX
by in utero electroporation led to precocious cell cycle exit and differentiation of neural stem cells followed by outward migration. Together these results indicate that
TLX
plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain.
...
PMID:Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain. 1790 Nov 27
