Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We examined 2 in formalin fixed hip specimens from a corpse, 27 patients with coxarthrosis and 3 healthy young volunteers with MRT concerning the illustration of the hip joint and pathological changes by coxarthrosis. Specimen of the femoral head after endoprosthetic operation could be achieved in 18 cases for comparison with MRT. All pathological alterations as cartilage alterations, sclerosis, cysts, effusion, edema, fibrosis were figured with high sensitivity. Cartilage was figured much better by gradient echo sequence with short echo time than by spin echo sequence. Gradient echo sequence made it possible to figure and quantify thinning of cartilage with high sensitivity. Both sequences showed artefacts because of the chemical shift in the area of the cartilage-bone boundary, which impaired especially the judgement of cartilage by spin echo sequence. Gradient echo sequence allowed because of the phase-contrast effect the distinction of hematopoietic and fatty bone marrow and possibly the delineation of bone marrow edema.
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PMID:[Experimental and clinical studies on the relevance of proton spin tomography in patients with coxarthrosis]. 794 85

Gilles de la Tourette syndrome (GTS) is characterized by multiple fluctuating motor and vocal tics. These tics are often preceded by premonitory phenomena including the urge to move, or by exaggerated bodily sensations that can lead to considerable disability and difficulties with attention and concentration. In the past the premonitory phenomena were interpreted as the driving force behind tics. However, there is not always a clear sequence of premonitory sensations followed by a tic. Also, the former typically develop around the age of 10 years, i.e. after the onset of the latter. Thus, the relationship between premonitory phenomena and tics is unclear. The present article reviews the current knowledge on this issue. Neurophysiological studies have shown some abnormalities of sensorimotor integration in GTS. In addition, structural imaging (MRT) has demonstrated a thinning of the sensorimotor cortex in children and adolescents with GTS. In contrast, an increase in fractional anisotropy as a marker of the directionality of white matter fibers underneath the pre- and postcentral gyrus has been demonstrated in adult GTS patients. These data underscore the role of developmental abnormalities and reorganisation in the somatosensory system in GTS warranting further studies. Multimodal studies including structural and functional imaging and electrophysiology in clinically well characterized GTS subgroups might foster a better understanding of somatosensory phenomena and the role of sensorimotor circuits in GTS.
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PMID:[Somatosensory phenomena and the role of sensorimotor circuits in Gilles de la Tourette syndrome]. 2156 7