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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anterior segment fluorescein angiography has been used in the investigation of patients with sclerokeratitis. This showed that corneal thinning or destruction was associated with non-perfusion of the episcleral vasculature. The changes arose either as a result of a systemic vasculitis in seropositive individuals or were induced by surgery to the eye. Infiltrative forms of sclerokeratitis were commoner in seronegative patients and were less often associated with vascular shutdown.
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PMID:Fluorescein angiography in the differential diagnosis of sclerokeratitis. 382 65

To date, there has been only one published report on the infectious sclerokeratitis caused by Metarhizium anisopliae, which is an entomopathogenic fungus. Regarding corneal infection, three reports have been published to date. Although the prognoses of the corneal infections are favourable, prognosis when scleral infection is involved is very poor. A 76-year-old patient presented with foreign body sensation in the left eye. Microscopic examination with Fungi Flora Y staining of the corneal scraping revealed fungal infection. The conjunctiva was melted by the infection over a wide area. Although intensive medications were administered, an emergency surgery was necessary because scleral thinning, corneal perforation and lens prolapse occurred. The fungal isolate was identified as M. anisopliae by sequencing the internal transcribed spacer region. Herein, we report the second known case worldwide of M. anisopliae sclerokeratitis, and we review the literature related to the ocular infections.
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PMID:Severe fungal sclerokeratitis caused by Metarhizium anisopliae: a case report and literature review. 2559 Sep 90