Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This two phase study was designed to observe the toxicity and effectiveness of retinoids on oral leukoplakia. The study design included patients who had visible and measurable oral leukoplakia without history of synchronous oral cancer or oral cancer within the previous 2 years. Documentation of the lesion by direct measurement and photography, as well as a biopsy at the beginning and at the end of the study (for verification of the histologic appearance of the lesion), were performed in each patient. Sixteen patients with oral leukoplakia were treated with 13-cis-retinoic acid formulated in a troche in the strength of 1 mg. Three patients received 3 mg/day, 8 patients received 5 mg/day, and 5 patients received 10 mg/day. The initial visible responding event appeared to be a thinning of the leukoplakia with reduction in the whitish surface leaving a reddish, velvety epithelium. If resolution occurred, the velvety area became pink, assuming the color and texture of the normal adjacent mucosa. Toxicity of the drug appeared to be acceptable among the evaluable patients. Of the 11 patients, 3 demonstrated complete response and 6 demonstrated partial response after 6 months of treatment with the drug under study. Recurrences developed in two of the three patients with complete response, and neither of the two showed complete histologic and cytologic regression. One of the patients with partial response went on to complete response after cessation of treatment. Under the condition of our study, a treatment effect was observed with small amounts of topical 13-cis-retinoic acid and that the level of toxicity was acceptable.
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PMID:Effect of retinoids on oral leukoplakia. 657 87

Perforator flaps are suitable for numerous reconstructive purposes. However, there are few data about their usefulness for intraoral reconstruction. We reviewed data of 101 patients who were reconstructed by two types of perforator flaps after oral cancer. Forty-six soleus perforator flaps and fifty-five anterolateral thigh (ALT) perforator flaps were performed. Procedural data and outcome measures were analyzed. One ALT and four soleus perforator flaps were lost, resulting in success rates of 97.8% and 91.4%, respectively. Soleus perforator flaps were more challenging due to short and small-caliber vessels, higher susceptibility to vascular spasm, and difficult prediction of the location of the vascular pedicle. All donor sites in both groups except one were closed directly, and their morbidity was negligible. Perforator flaps from both donor sites can be used for intraoral reconstruction with good functional results; however, despite primary thinning, the ALT flap can be voluminous in small and flat defects. Here, soleus perforator flaps adapt better to the oral mucosa. The ALT perforator flap is more reliable and serves as a safe alternative to the radial forearm flap.
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PMID:Suitability of the anterolateral thigh perforator flap and the soleus perforator flap for intraoral reconstruction: a retrospective study. 2142 89