Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neurologic disease is reported to occur in just 10% of patients with mixed connective tissue disease (MCTD). Most commonly, this is manifested by mild trigeminal neuralgia. This report details the clinical and neuropathologic findings of transverse myelitis in a patient with MCTD. Neurologic features include progressive areflexic paraplegia with loss of bowel and bladder function. Neuropathologically there was thinning of the thoracic cord, widespread loss of axons and myelin sheaths, reactive astrocytosis, macrophage formation, vascular thickening with perivascular chronic inflammatory cell infiltration, and calcium deposits. This case demonstrates that severe neurologic disease unresponsive to therapy can occur in MCTD.
 ...
PMID:Transverse myelitis in mixed connective tissue disease. 73 23

Operations were performed at four different levels on the fifth nerve of the monkey to determine which procedure offers the best chance of avoiding ocular complications after surgical treatment of trigeminal neuralgia (Figure 18). (1) Section of the ophthalmic branch of N V results in immediate corneal anesthesia. After one week, chromatolysis of the unipolar gasserian ganglion cells subserving the first division occurs and Wallerian degeneration of the corneal nerves of the ipsilateral eye is seen. This is associated with perilimbal round cell invasion of the superficial cornea and subconjunctival area. In addition, iritis develops de novo or becomes worse if it pre-exists. Miosis occurs, but the chemodiagnostic tests of cocaine and adrenalin indicate an intact sympathetic system. The cause for this inflammatory reaction and pupillary change is unexplained by this study. The intraocular pressure is slightly lower on the side of the section than in the normal fellow control eye after surgery, but the difference is not statistically significant. (2) Section of the posterior sensory root of N V in the middle cranial fossa at a point between the gasserian glanglion and the tentorium results in similar ocular changes as is seen after interrupting the ophthalmic division alone. Wallerian degeneration of the corneal nerves, however, is not seen after seven, twelve or twenty-one days. (3) Transtentorial section of the trigeminal posterior sensory root performed in the middle cranial fossa, results in immediate corneal anesthesia. The gasserian ganglion cells, however, remain healthy and there is no perilimbal round cell invasion of the superficial cornea or subconjunctival tissue. Miosis occurs but the chemodiagnostic tests of cocaine and adrenalin indicate an intact sympathetic system. The intraocular pressure is only slightly lower on the side of section than in the control eye, but the difference is not statistically significant. (4) Suboccipital rhizotomy of the posterior sensory root of NV at the pons results in immediate corneal anesthesia. The gasserian ganglion cells remain healthy and there is no perilimbal round cell invasion of the superficial cornea or subconjunctival tissue. Miosis occurs in most animals (2 of 3) and is associated with an intact sympathetic system as indicated by the chemodiagnostic tests of cocaine and adrenalin. Intraocular pressure is very slightly lower on the side of section than in the control eye, but the difference is not statistically significant. (5) Thinning of the corneal epithelium occurs in an anesthetic eye regardless of the location of the section of N V and is not adversely affected by tarsorrhaphy. The corneal stroma, however, remains unchanged. (6) The experimental data demonstrate that to decrease ocular complications, operations on the trigeminal nerve should be performed on the caudal end of the sensory root as far from the gasserian ganglion as is techanically feasible.
 ...
PMID:The anesthetic eye: an investigation of changes in the anterior ocular segment of the monkey caused by interrupting the trigeminal nerve at various levels along its course. 81 49

From a series of 110 cases of surgically treated trigeminal neuralgia the author reports two cases in which impressio basilaris was the cause of neuralgia. One of these patients was operated on by the method of Frazier-Spiller, the other by Dandy's method in a microsurgical modification. These two methods gave the author an opportunity of comparing intraoperative findings in the middle and posterior cranial fossa. In the middle cranial fossa besides deformity of the base of the skull thinning was found of the dura, flattening of Gasser's ganglion and the postganglionic fibres of the trigeminal nerve were taut on the edge of the pyramid. In the posterior fossa the pontocerebellar angle was crowded despite removal of some cerebrospinal fluid. The postganglionic fibres of the trigeminal nerve were closely adherent to the pons and were visible on a small distance from the tentorium to the pons. In both cases postganglionic rhizotomy was done and the patients were relieved from pain.
 ...
PMID:[Causative relationship between cranial base deformities and trigeminal neuralgia]. 409 46

We report a hitherto undescribed persistent carotid vertebral anastomosis associated with ipsilateral internal carotid artery agenesis and bilateral duplication of the intradural vertebral arteries. This rare anomaly was detected on MRI, supplemented by CT angiography while evaluating for cause trigeminal neuralgia in a 37-year-old woman. The aberrant vessel was seen to cause thinning and lateral displacement of the left trigeminal nerve on CISS 3D images. Also noted was a bilateral vertebral artery duplication of the PSA variant with the posterior inferior cerebellar artery arising from the medial limb of the duplication on the left.
 ...
PMID:Trigeminal neuralgia caused by a new variant of persistent trigeminal artery associated with agenesis of internal carotid artery. 2867 46