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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical and pathologic findings of a case of congenital bilateral, peripheral corneal leukoma associated with iris coloboma and anterior subluxation of the lens are reported. The changes in the region of keratolenticular apposition include partial absence of Bowman's membrane, stromal vascularization and thinning with large-diameter collagen fibrils, and absence of Descemet's membrane and endothelium. The authors postulate that dysembryogenesis of the tertiary vitreous, with iris coloboma, resulted in apposition of the lens to cornea during the second and third month of gestation and that this apposition resulted in the observed peripheral corneal abnormalities.
J Pediatr Ophthalmol Strabismus
PMID:Peripheral Peters' anomaly: a histopathologic case report. 31 Aug 74

A marked reaction postoperatively was noted following strabismus surgery for thyroid ophthalmopathy. Preoperatively, the right eye was noted to have a small amount of lower nasal conjunctival injection and chemosis while the left eye was quiet. Only the right eye had the severe inflammatory reaction postoperatively, while the left eye responded normally. The findings included marked proptosis, chemosis, subconjunctival hemorrhage, corneal exposure and drying with a sterile ring infiltrate, corneal thinning and vascularization, and ocular immobility. The treatment and course of these complications is described. It is suggested that muscle surgery be deferred in patients with thyroid ophthalmopathy when there are signs of continued inflammation.
J Pediatr Ophthalmol Strabismus
PMID:Complications following surgery for thyroid ophthalmopathy. 654 69

Terrien's disease is an uncommon (Terrien himself saw only three cases in thirty years of practice) corneal condition characterized by vascularization, opacification, lipid deposition, and thinning. With progression, large degrees of astigmatism occur and perforation is a threat. One-third of cases exhibit an inflammatory component. While typically described as a disease of middle to late age, these four cases indicate the full spectrum of clinical disease may be seen by an ophthalmologist who cares for children.
J Pediatr Ophthalmol Strabismus
PMID:Terrien's marginal corneal degeneration. 698 Feb 70

We report a case of progressive deviation of an implant that resulted in conjunctival thinning and an inadequately fit prosthesis. Such a case may have been treated with conjunctival grafting or replacement of the implant with an hydroxyapatite sphere. In this case, injection of botulinum A toxin (Botox) into the contracted medial rectus muscle contributed to the successful refitting of a new and stable prosthesis and improvement of the conjunctival integrity. Possible explanations of the progressive shift in the position of the implant and its postinjection stability are discussed.
J Pediatr Ophthalmol Strabismus
PMID:Botulinum A toxin treatment of a deviated orbital implant. 763 2

An euthyroid patient was referred for compressive optic neuropathy in Graves' disease. Under prednisone therapy the right and left visual acuities were 1.0 and 0.4, with a profound decrease in color vision on the left. Bilateral anterior orbital decompressions were performed. When prednisone was withdrawn postoperatively, the visual acuity of the right eye dropped to 0.32 with bilateral complete failure on the Ishihara color test. A biopsy of the inferior oblique muscle of the left eye confirmed Graves' disease and additional transantral decompression of the right orbital apex was performed. Under intravenous methylprednisolone therapy, the visual acuity dropped postoperatively to 0.2 and 0.4, respectively. 15 U botulinum toxin were given by retrobulbar injection between the inferior and lateral rectus muscles. Four days later the patient called and said that the visual acuity in the right eye had improved tremendously. Two weeks after the injection the visual acuity was 0.7 in both eyes, although prednisone had been reduced to 20 mg by that time. The convergent strabismus had increased but the already severely restricted motility of the right eye had been little affected by the retrobulbar injection, and adduction not at all. Orbital CT-scan showed thinning of the inferior and lateral rectus muscles, but not of the medial rectus.
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PMID:Botulinum toxin as adjunct for refractory compressive optic neuropathy in Graves' disease. 1204 25

Two brothers with very similar phenotypes involving trichiasis (misdirected lashes), entropion with corneal abrasions, strabismus, progressive thinning of the scalp hair, sensorineural hearing impairment, mild learning difficulties, and inguinal hernias are described. They have similar, distinctive facial features with deep-set eyes, a high nasal bridge and a short philtrum. Both brothers are carriers of a maternally inherited apparently balanced translocation of chromosomes 11 and 18: 46,XY, t(11;18)(p13;q21)mat. However, this is thought to be coincidental, since their younger brother also carries this translocation and is phenotypically normal. Although they have many features that are found in the ectodermal dysplasia syndromes, their combination of features is distinct and has to our knowledge not been previously reported.
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PMID:Two brothers with trichiasis, entropion and corneal scarring, sensorineural hearing loss, progressive thinning of scalp hair, mild learning difficulties and distinct facial features. A new syndrome? 1505 21

Eye muscle surgery in strabismus patients usually is without serious, vision-threatening complications. The risk of scleral perforation during strabismus surgery has been reported to approximately 1% but usually without serious sequelae. Inadvertent perforation may occur during muscle disinsertion or during muscle reattachment. The risk of perforation is increased in myopic eyes, and the risk is higher in recessions than in other strabismus procedures. We report a case of sudden rupture of the globe during a recession procedure on the superior rectus muscle caused by a localized area of extreme scleral thinning adjacent to the muscle insertion. To our knowledge, this serious complication has not previously been reported.
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PMID:Localized, extreme scleral thinning causing globe rupture during strabismus surgery. 1641 31

Unilateral stromal keratitis is a known rare sequela of primary varicella infection. The authors describe a unique case of immunological (Wessely) ring formation and progressive ring thinning following primary varicella infection in a 6-year-old girl.
J Pediatr Ophthalmol Strabismus
PMID:Ring corneal infiltrate and progressive ring thinning following primary varicella infection. 1840 61

Isochromosome 18p (i(18p)), is a rare chromosomal disorder that occurs once in about every 140,000 live births and affects males and females equally. Most of the cases are due to a de novo formation but in the literature familial cases were reported. Here, we report a young female with dysmorphic features as microcephaly, frontal bossing, strabismus, low-set ears, small pinched up nose, small mouth, high palate and long philtrum, presenting a small metacentric chromosome. Besides the dysmorphic features she also has gastroesophageal reflux, spasticity, strabismus and specific brain MRI findings as dilatation of the right lateral ventricle trigonum occipital horn (colpocephaly), thinning of the corpus callosum especially of the posterior part and abnormality of the white matter myelinisation at the frontal and occipital region. Particularly the MR findings are rarely reported in the literature.
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PMID:A case with a rare chromosomal abnormality: isochromosome 18p. 2042 32

Goltz syndrome is a rare multisystem disorder with cutaneous, ocular, dental and skeletal abnormalities. Other mesoectodermal abnormalities are also present. Its hallmark is thinning of the dermis resulting subcutaneous fat herniation. The present case is a 5 year old girl having linear skin atrophy with fat herniation, skeletal abnormalities in the form of polysyndactyly, facial asymmetry, squint with coloboma iris, deformed pinna, abnormal dentition, umbilical hernia along with osteopathia striata of long bones which is consistent with Goltz syndrome. We are presenting this case due to its rarity.
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PMID:A case report of focal dermal hypoplasia-Goltz syndrome. 2398 48


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