Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hydatid disease is a parasitic disease most commonly caused by Echinococcus granulosus that seldom involves the skeleton and is still common in the countries of the temperate zones. We present an extremely rare case report of a young patient with humeral hydatid disease complicated with extraosseous involvement. Plain film of the left humerus demonstrated distortion of the axis, regional expansion of the humeral shaft with minimal thinning areas of the cortex. Additionally, numerous radiolucent areas of the humeral shaft were observed especially at the distal part of the bone. No calcification of the soft tissues was noticed. Computed tomography examination showed significant destruction of the trabecular bone of the humeral head and polycystic appearance of the bone marrow with regional calcifications into the lumen. Additionally, a large cystic lesion between medial and lateral head of the triceps muscle with some foci of calcifications were observed. Magnetic resonance imaging revealed the multiocular nature of the lesion into the humeral lumen with a cystic lesion involving the soft tissues of the upper arm. The cyst showed contrast enhancement at the pericyst capsule of the cyst after Gadolinium-DTPA administration.
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PMID:Humeral hydatid cyst complicated with extraosseous involvement: a case of unusual location of echinococcosis. 1122 80

Schistosomiasis is a parasitic disease with a global health impact second only to malaria. The World Health Organization has classified schistosomiasis as an illness for which new therapies are urgently needed. However, the causative parasite is refractory to current high-throughput drug screening due to the diversity and complexity of shape, appearance and movement-based phenotypes exhibited in response to putative drugs. Currently, there is no automated image-based approach capable of relieving this deficiency. We propose and validate an image segmentation algorithm designed to overcome the distinct challenges posed by schistosomes and macroparasites in general, including irregular shapes and sizes, dense groups of touching parasites and the unpredictable effects of drug exposure. Our approach combines a region-based distributing function with a novel edge detector derived from phase congruency and grayscale thinning by threshold superposition. The method is sufficiently rapid, robust and accurate to be used for quantitative analysis of diverse parasite phenotypes in high-throughput and high-content screening.
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PMID:Segmenting the etiological agent of schistosomiasis for high-content screening. 2342 18