Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Desmoplastic fibroma (DF) is a rare intraosseous benign neoplasm that represents less than 1% of the osseous tumors. This lesion can be locally aggressive, and the rate of recurrence is frequently high.A 34-year-old male patient was referred to our clinic presenting a tumor in the anterior zone of the maxilla. The oral examination revealed a hard and lobulated tumor, affecting teeth 13 to 26. The radiographic examination, orthopantomography, and computed tomography revealed a radiolucent, multilocular, well-defined image, which extended from tooth 13 to the mesial root of tooth 26, provoking marked expansion, thinning, and perforation of the buccal and palatal cortical plates. A provisional diagnosis of aggressive odontogenic tumor was made, and block resection of the tumor was carried out. Intraoperatively, the tumor was lobulated, composed of a homogenous fibrous tissue, hard, and white-yellowish. The histologic analysis leads to a diagnosis of DF.Desmoplastic fibroma of the oral cavity is a rare benign intraosseous tumor, especially when it involves the upper maxilla and the anterior region. The main clinical and pathologic differential diagnosis in our case was central odontogenic fibroma. The most suitable treatment option for DF of the oral cavity is a controversial issue, but block resection is the therapy reporting a lower recurrence. Finally, an interesting feature of this intraosseous neoplasm, if located in the oral cavity, refers to the different clinical pattern that might present depending on location.
 ...
PMID:Giant desmoplastic fibroma in the anterior zone of the maxilla. 2213 75

Odontogenic tumors present as locally invasive, slow growing, firm swellings on the face. They are rare in all species and are characterized histologically by the degree of differentiation and dental tissue of origin. Radiographic appearance is not pathognomonic for these lesions. Computed tomographic (CT) examination allows exact determination of tumor extension and aggressiveness. The objectives of this retrospective, case series study were to describe the clinical presentation, CT characteristics, and outcome in horses with histologically confirmed odontogenic tumors, and to identify imaging features suggestive of individual types of tumors. Four ameloblastomas, two ameloblastic carcinomas, three ameloblastic fibromas, and two complex odontomas were included. All but one complex odontoma presented as a single mass. All tumors were associated with maxillary or mandibular bone expansion, alveolar and cortical bone lysis, and cortical bone thinning. The majority also had cortical bone thickening and periosteal proliferation. All tumors contained some degree of mineral attenuation, although only the complex odontomas contained enamel attenuation allowing differentiation from other types of odontogenic tumors in this study. Ameloblastomas were found to have variable CT characteristics likely due to the sub-groups of ameloblastomas. Both ameloblastic carcinomas contained a mixture of mineralized and soft tissue attenuating material whereas ameloblastic fibromas were mainly composed of soft tissue attenuating material. Computed tomographic characteristics of odontogenic tumors generally indicate that they are expansile, aggressive tumors and can occur in a wide range of ages. Further investigation is needed to elucidate differences between each type of equine odontogenic tumor.
 ...
PMID:Equine odontogenic tumors: Clinical presentation, CT findings, and outcome in 11 horses. 3135 53