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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In summary, sinusitis is a common disease caused by viruses, bacteria and the accumulation of excessive secretions and inflammatory mediators that impair the function of the mucociliary transport. Combination treatment is usually necessary to treat the cause and relieve the symptoms of sinusitis. Therapy aims at eliminating causative bacteria with antibiotics, decongesting edematous membranes, and thinning mucus with use of a mucolytic-expectorant. Improving the rheology of mucus by thinning abnormally thickened secretions may improve mucociliary transport and enhance penetration of antibiotics. Acute sinusitis usually responds to treatment within 2 weeks. However, if treatment is unsuccessful or a severe complication occurs, intravenous antibiotics may be necessary along with antral puncture and lavage. In resistant cases, an appropriate surgical procedure may enhance the drainage.
Ear Nose Throat J 1992 Jun
PMID:Sinusitis--inspecting the causes and treatment. 145 72

A 70-year-old woman with an upper respiratory infection sustained an orbital floor fracture after vigorous nose blowing. The injury was complicated by orbital emphysema and cellulitis. CT scanning confirmed orbital floor fracture and associated orbital soft tissue herniation into the maxillary antrum. A follow-up sinus endoscopy three months later showed a healed periosteum and mucosa, but continued orbital herniation. As the patient's symptoms had largely resolved, repair was averted. Follow-up after nine months showed no recurrence of orbital swelling. The case presented illustrates a rare complication of vigorous nose blowing, coupled with thinning of the sinus walls seen in aging.
Ear Nose Throat J 1996 Mar
PMID:Orbital floor fracture following nose blowing. 872 Oct 22

Surgery in the elderly requires a knowledge of the changes in the larynx that take place with aging. In the elderly larynx, there are changes in the elastin and collagen fibers within the lamina propria. There is also thinning and atrophy of the mucous membranes and atrophy of the mucous glands. Common disorders are vocal fold atrophy, sulcus vocalis, glottic incompetence, and vocal fold edema. A reduction in the number of lymphatic channels is responsible for the vocal fold edema. Vocal fold atrophy is responsible for the increase in pitch that is frequently heard in elderly men. Other common conditions in the elderly include vocal fold nodules, polyps, and Reinke's edema. The most common phonosurgical procedures performed in the elderly are vocal fold surgery for benign pathology and laryngeal structure surgery for glottic incompetence. Microsurgical techniques on benign vocal fold lesions aim to avoid injury to the transitional layer, which is rich in fibroblasts. Although the superficial layer of the lamina propria involves less fibroblastic activity, any surgical manipulation of the lamina propria can influence the vibratory properties of the vocal folds, particularly when the basement membrane zone is manipulated. The alterations in phonosurgical techniques used in the elderly are the result of histologic changes in the vocal folds and altered wound healing. Functional voice disorders often develop to compensate for the structural changes in the larynx. Correction of hyperfunctional or abnormal functional technique is as important as phonosurgical correction of vocal fold pathology.
Ear Nose Throat J 1999 Jul
PMID:Phonosurgery in the elderly: a review. 1042 27

We treated a 38-year-old man who had a large septal perforation that had been caused by chronic nasal inhalation of cocaine. We were able to repair the perforation with a left radial forearm free flap. Long-term followup indicates a successful closure of the defect and a natural thinning of the flap. The patient remains symptom-free more than 2 years following surgery.
Ear Nose Throat J 2001 Aug
PMID:Repair of a large septal perforation with a radial forearm free flap: brief report of a case. 1152 66

We report a case of otogenic pneumocephalus in an 80-year-old woman with multiple myeloma. The pneumocephalus was associated with Haemophilus influenzae otitis media and reactive meningitis in the absence of an intracranial brain abscess. Myeloma causes thinning of bone trabeculae and destructive lytic bone lesions. This can predispose to a risk of pathologic fractures and, in patients with skull vault involvement, to the rare complication of pneumocephalus. Therefore, pneumocephalus should be considered in the differential diagnosis of acute headache in patients with multiple myeloma, especially those with skull vault involvement. Prompt computed tomography and liaison between the otolaryngology and neurology teams may assist in making an early diagnosis and preventing life-threatening intracranial complications.
Ear Nose Throat J 2012 Sep
PMID:Otogenic pneumocephalus as a complication of multiple myeloma. 2299 13