Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Severe nail dystrophy is a recently described acquired nail disorder. The nails are variably involved and may show thinning, thickening, pitting, ridging, koilonychia, opalescence, and loss of luster. Not uncommonly, some nails are completely spared. Although most of the cases reported were among children, and nail changes showed gradual resolution, in a few cases the disorder is seen in adulthood. We recently investigated a pedigree extending through five generations in which twenty-one of the thirty-seven members were variably afflicted with the dystrophic nail changes. To our knowledge, the familial pattern, inherited as an autosomal dominant trait, has never been previously reported. We propose the term "familial severe twenty-nail dystrophy" for the disorder in this family.
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PMID:Familial severe twenty-nail dystrophy. 713 Apr 95

Worn-down nail syndrome is a nail disorder characterized by thinning of the distal nail plate caused by repetitive chemical or mechanical trauma. We present a previously undescribed source of worn-down nail syndrome caused by trauma from nail filing after acrylic nail removal.
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PMID:Worn down nails after acrylic nail removal. 2561 31

Focal dermal hypoplasia (FDH) is an X-linked dominant disease characterized by dermal thinning and fat herniation with other ectodermal and mesodermal abnormalities. There is limited literature regarding the symptomatology and progression of skin, hair, and nail disease. The risk of bone fragility has not been explored either. This cross-sectional survey-based study explored these gaps in knowledge and provides direction for future avenues of research in FDH.
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PMID:Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia. 2802 44

Worn-down nail syndrome is a nail disorder characterized by thinning of the distal nail plate induced by repetitive mechanical trauma. A French variant, entitled "bidet nail syndrome" was first described by Baran.
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PMID:Bidet nail syndrome: report of a typical case. 2854 86

Onychomycosis is the most common nail disease. There are various treatments available, the majority of which are topical and systemic therapies. However, the poor nail penetration, systemic side effects and the poor compliance of the patients lead to limited efficacy. Photodynamic therapy may be an option. Yet, the penetration of photosensitizer into the nail plate needs to be improved. Here, we report a case of onychomycosis successfully treated with 20 % 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT). Toenail thinning with a common nail file was given before PDT. This suggest that thinning toenails, combining with topical ALA-PDT may be an effective, feasible, and safe alternative for the treatment of onychomycosis, especially for cases recalcitrant or inappropriate to other conventional therapies.
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PMID:Combination of toenail thinning and photodynamic therapy in distal and lateral subungual onychomycosis treatment: A case report. 3210 22