Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty-one preterm children (29 with spastic diplegia and 12 without motor deficits) who had a normal verbal IQ were studied to clarify the clinical significance of neuroanatomical abnormalities disclosed by T1-weighted and T2-weighted magnetic resonance imaging (MRI). Both types of images clearly showed abnormalities in the frontal corona radiata of the children with spastic diplegia, while there were no abnormalities in the children without motor deficits. We compared the T1-weighted imaging findings with deficits of higher brain functions, evaluated by the performance subtests of the Wechsler Intelligence Scale. Thinning of the parietal and/or occipital white matter was noted in children with visuospatial cognitive deficits. Thus, MRI may be helpful in confirming early clinical suspicions of visuospatial cognitive deficits as well as motor deficits in preterm children, especially those with spastic diplegia.
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PMID:MRI changes and deficits of higher brain functions in preterm diplegia. 808 28

Twelve patients with spastic diplegia (SD) and visuoperceptual impairments from preterm birth were evaluated for electroencephalogram (EEG) spectral power density, interhemispheric (ICoh) and intrahemispheric (HCoh) coherence, and asymmetry of coherence between the right and left hemispheres in and compared with normal children under resting conditions. There were no significant differences in EEG spectral power density. The SD group revealed lower ICoh at the occipital pair for the alpha band (P = .0034) and a higher value at the frontal pair for the theta band (P = .0047). Higher HCoh in SD was pronounced in the left hemisphere for the delta, theta, and beta bands (P < .01). There were no higher values in the control group. Higher HCoh asymmetry was exhibited in the left hemisphere in the control group, while very little asymmetry was found in the SD group. In both groups 91.7% were classified correctly by discriminant analysis. We suggest that these neurophysiologic abnormalities in preterm SD children correspond neuroanatomically to the callosal thinning and neuropsychologically to the visuoperceptual impairments.
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PMID:Electroencephalographic coherence abnormalities in preterm diplegia. 949 92