Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The amount of human growth hormone (HGH) decreases significantly after the age of 30. This decrease has been implicated as one of the major causes in the signs of aging, such as thinning of the skin and bones, a decrease in lean muscle mass and an increase in adipose tissue. Supplementing the body's dwindling supply with recombinant human growth hormone (rHGH) has been shown to reverse the signs and symptoms of aging. However, drawbacks in rHGH replacement therapy include prohibitively high cost, the need for repeated injection and side effects such as carpel tunnel syndrome, gynecomastia and insulin resistance. The purpose of this study was to establish an in vitro model using genetically-engineered keratinocytes to screen natural compounds for the ability to stimulate HGH secretion. We now report that a combination of equal amounts of L-arginine and L-lysine, aged garlic extract (Kyolic), S-allyl cysteine and Pycnogenol significantly increased secretion of HGH in this in vitro model. The data indicate that this in vitro model may be used to screen for other secretagogues.
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PMID:Kyolic and Pycnogenol increase human growth hormone secretion in genetically-engineered keratinocytes. 1212

The male chest has a female appearance in patients with gynecomastia and those who have experienced a huge weight loss. The disadvantages of reduction mammaplasty for men are the visible scars on the chest wall necessitated because of skin redundancy. The aims of the chest-lifting procedure are to reposition the breast, to create a male appearance by thinning the amount of glandular and fatty tissue, to avoid noticeable scars on the chest wall, and to hide the scar in the middle axillar line.
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PMID:Chest lifting. 1673 72