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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The report describes a method for a simple animal experiment in which esophageal changes similar to megaesophagus can be produced by distal esophageal constriction. Whereas the esophagus of the operated rats with distal stenosis of the esophagus underwent no change in length, there was an increase in width, especially in the middle third, by an average of about 4.5 times. Optical microscopy revealed no inflammatory infiltrates in the esophageal mucosa as a possible indication of retention esophagitis in any of the animals. The histomorphometric investigation of the various portions of the esophageal wall revealed, during the initial period (12 days), a statistically significant thinning of the submucosa and muscularis in almost every region of the esophagus. An early hypertrophy of the tunica muscularis in almost every region of the esophagus. An early hypertrophy of the tunica muscularis was observed only in the area of the distal stenosis. The cornifying squamous epithelium showed a slight increase in thickness in the middle and distal regions of the esophagus. The animal experimental model presented here appears to us to be well suited for further investigation of functional esophageal disorders through future animal experiments.
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PMID:Megaesophagus: induction by a simple animal experiment. Report on the method. 381 92

Non-malignant oesophageal diseases are critical to recognize, but can be easily overlooked or misdiagnosed radiologically. In this paper, we cover the salient clinical features and imaging findings of non-malignant pathology of the oesophagus. We organize the many non-malignant diseases of the oesophagus into two major categories: luminal disorders and wall disorders. Luminal disorders include dilatation/narrowing (e.g. achalasia, scleroderma, and stricture) and foreign body impaction. Wall disorders include wall thickening (e.g. oesophagitis, benign neoplasms, oesophageal varices, and intramural hematoma), wall thinning/outpouching (e.g. epiphrenic diverticulum, Zenker diverticulum, and Killian-Jamieson diverticulum), wall rupture (e.g. iatrogenic perforation, Boerhaave Syndrome, and Mallory-Weiss Syndrome), and fistula formation (e.g. pericardioesophageal fistula, tracheoesophageal fistula, and aortoesophageal fistula). It is the role of the radiologist to recognize the classic imaging patterns of these non-malignant oesophageal diseases to facilitate the delivery of appropriate and prompt medical treatment.
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PMID:Imaging of the oesophagus: beyond cancer. 2830 54