Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Intrasellar arachnoid cyst is very rare. We report a case of intrasellar arachnoid cyst and review 15 cases which were previously reported. A 58-year-old male was admitted for evaluation of visual disturbance on April 24, 1981. Neurological examination revealed bilateral decreased visual acuity, optic atrophy and bitemporal hemianopsia. X-ray film of the skull showed a balloon-shaped sella turcica with thinning of the cortex of the sella floor. Axial and coronal CT scan showed a cystic lesion with water-density occupying the intrasellar and suprasellar region. After administration of contrast medium, no enhancement was noted. Bilateral carotid angiographies demonstrated that the carotid siphons were stretched and displaced laterally, the A1 portions of the anterior cerebral arteries were raised. Pneumoencephalography revealed the upward displacement of the floor of the third ventricle indicating the presence of the suprasellar mass. On May 7, 1981, the sella turcica was reached via the transsphenoidal rhinoseptal approach. A cyst with a white colored thin wall which contained water-like fluid was encountered, and a biopsy was taken of the cyst wall. The roof of the cyst pulsated downward and ruptured spontaneously. Cerebrospinal fluid flowed out. The cavity was filled with muscle and adipose tissue. Postoperative course was uneventful during the first few days and the visual disturbance improved. On the fourth postoperative day cerebrospinal fluid rhinorrhea occurred, but it subsided in nine days. The patient was discharged on June 26 with satisfactory improvement of visual field and visual acuity. Histological examination of the biopsied specimen revealed arachnoid membrane consisting of collagen fibers and scattered cells. Symptoms, signs and radiological findings of the intrasellar archnoid cyst are similar to that of various sellar lesions including pituitary adenoma, craniopharyngioma and the other space occupying mass in the sellar region. Intrasellar arachnoid cysts can be treated by a transsphenoidal approach as well as a subfrontal approach with craniotomy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[A case of intrasellar arachnoid cyst]. 646 41

Intrasellar arachnoid cyst is very rare. We report a case of intrasellar arachnoid cyst. A 44-year-old male was admitted for evaluation of his headache and visual disturbance on August 6, 1993. Neurological examination revealed bilateral decreased visual acuity and visual field defect. Endocrinological examination showed panhypopituitarism. Other neurological findings were normal. X-ray film of the skull showed a ballooning dilation of the sella turcica with thinning of the sellar floor. CT scan showed a cystic lesion with CSF-density occupied the sella. After intravenous administration of contrast medium, the cyst showed no enhancement. MRI showed the intrasellar mass had the same characteristics as the surrounding subarachnoid space. Bilateral carotid angiographies demonstrated that the carotid siphons were stretched and displaced laterally, and the A1 portions of the anterior cerebral arteries were raised. We made a diagnosis of intrasellar cystic lesion. On August 18, the sella turcica was opened via the transsphenoidal rhinoseptal approach. The cyst contained CSF-like fluid, and a part of the cyst wall was resected. The cavity was filled with Gelfoam and the sellar floor was repaired with bone flap. Postoperatively, the patient's visual disturbance improved, but diabetis insipidus appeared and required hormonal replacement. The patient was discharged on September 27 with improvement of visual acuity and visual field. Histological examination demonstrated that the cyst wall consisted of thick arachnoidal cells with fibrous connective tissue. The arachnoidal cells with oval nuclei was stained with epithelial membrane antigen. Symptoms, signs and radiological findings of intrasellar arachnoid cyst are similar to those of various sellar lesions including pituitary adenoma, craniopharyngioma, empty sella, Rathke's cleft cyst, epidermoid et al.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Intrasellar arachnoid cyst: a case report]. 756 27