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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a case of keratotorus on both sides with extreme thinning of the cornea first a lamellar and in a second sitting a perforating keratoplasty was performed. Surgical approach and postoperative results are discussed.
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PMID:[Contribution to clinic and pathohistology of keratotorus (author's transl)]. 731 95

Description of a patient with keratoconus posticus acutus. The typical changes including thinning, were seen clinically on the posterior central surface of the left cornea with conical protrusion of the internal curvature. The right eye showed the classic signs of the acute phase.
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PMID:[A case of Keratokonus posticus acutus (author's transl)]. 734 18

Eight myopic patients wearing Permalens contact lenses continuously for 18 months were monitored for corneal thickness changes. The averaged results showed maximum corneal swelling after 1 week of wear with the cornea gradually returning to near prefitting thickness levels. However, great individual variation in corneal thickness response was noted with some patients showing chronic corneal thickening and some showing corneal thinning after the 18-month wearing period.
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PMID:Corneal thickness changes with extended contact lens wear. 744 83

We report on a 10 1/2-years-old patient with clinical manifestations of Peters'-Plus syndrome. The patient had Peters' anomaly, slightly arched eyebrows, long eyelashes, a broad nasal tip; malformed and prominent ears, cleft lip and palate, brachydactyly, fingertip pads, severe growth deficiency, and mild mental retardation. Peters' anomaly is a defect of the anterior chamber of the eye, including central corneal opacity, thinning of the posterior aspect of the cornea and iridolenticulocorneal adhesions. Peters'-Plus syndrome is a disorder in which patients with Peters' anomaly are also found to have short stature, brachymedia, abnormal ears, cleft lip and palate, and mental retardation. Our patient showed Peters'-Plus syndrome associated with some clinical manifestations of the Kabuki make-up syndrome.
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PMID:Peters'-Plus syndrome: report on an unusual case. 761 2

A 30-year-old man with keratoconus in the right eye had radial keratotomy in the left eye. Two pairs of corneal relaxing incisions (CRIs) were made in the right eye to flatten the central cornea and reduce high astigmatism. The right eye required an enhancement, and two additional arcuate CRIs were made. A corneal ulcer developed in the right eye, with infiltrates in the incision and corneal thinning. Although the second set of CRIs resulted in more regular astigmatism, the corneal thinning and ulcer caused regression at two months postoperatively. A wedge resection was performed to even the irregular astigmatism. The results are presented.
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PMID:Wedge resection in the cone after failed refractive surgery in a patient with keratoconus. 855 30

A 24-year-old man presented with narrow, linear areas of thinning situated horizontally in the upper part of both corneas. These areas were associated with progressive corneal ectasia, causing high degrees of "against the rule" astigmatism. By excising the affected areas, the refractive error was significantly improved in both eyes. Features of the disease suggested that the condition was related to the other ectatic corneal dystrophies.
Cornea 1995 Jan
PMID:Bilateral linear corneal ectasia. An unusual case and its surgical management. 771 29

In the case reported, herpes virus I after having caused relapsing keratitis in an eye promoted the formation of a severe corneal ulcer caused by Scopulariopsis brevicaulis, a saprophytic mycete found in soil, which only once has been described as the cause of keratitis in man. Scopulariopsis was identified microscopically after culturing the conjunctival secretion on Sabouraud dextrose agar medium, while DNA probe tests confirmed the absence of herpes virus I. Topical and oral administration of miconazole and scraping of the corneal infiltrate dispersed the infection. Subsequently local steroids were given to reduce the neovascularization, and a therapeutic contact lens was applied because of intercurrent corneal thinning. Three months after beginning antifungal therapy, the visual acuity had increased from 1/120 to 1/10. The case described confirms that S. brevicaulis can cause opportunist infections in a cornea previously damaged by a different agent.
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PMID:Fungal keratitis due to Scopulariopsis brevicaulis in an eye previously suffering from herpetic keratitis. 784 51

To examine whether collagen crosslinking is important for the regulation of refractive development, tree shrews were treated with agents that block collagen crosslinking [beta-aminoproprionitrile (beta-APN), or D-penicillamine (DPA)] and underwent monocular deprivation (MD) of form vision by eyelid closure to induce myopia. MD began on the first day of visual exposure and continued for 75 days. After 15-20 days of visual exposure, daily intraperitoneal injections of beta-APN (beta-APN MD animals, n = 5) or DPA (DPA MD animals, n = 5) were administered for 17-21 days. beta-APN open animals (n = 5) received the same injection schedule, but both eyes remained open. Saline MD animals (n = 5) received i.p. saline and MD. At 75 days of visual exposure, the MD eyes of beta-APN treated tree shrews were highly myopic (-23.6 +/- 3.3 D) in comparison to their open control eyes. This was markedly greater than the difference in saline MD animals (-11.0 +/- 0.8 D). DPA MD animals showed a relative myopia of -14.3 +/- 2.2 D. The structural correlate of the myopia, elongation of the vitreous chamber in the deprived eyes relative to the control eyes, was significantly greater in the beta-APN MD animals 0.53 +/- 0.03 mm, which was not significantly different from the saline MD group. Thinning of the posterior sclera, but not the cornea, was observed in the deprived eyes of beta-APN treated tree shrews, along with a tessellated appearance to the fundus. The eyes of the beta-APN open animals showed no significant differences from normal. Beta-APN MD and DPA MD treated chickens did not develop greater myopia or vitreous chamber elongation than standard MD chickens. The selective effect of the lathyritic agents on the deprived eyes in tree shrew suggests that collagen crosslinking interacts, in the mammalian sclera, with a retinally-derived signal to regulate the elongation of the eye in myopia.
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PMID:Prevention of collagen crosslinking increases form-deprivation myopia in tree shrew. 785 23

Keratoconus is a noninflammatory corneal disorder characterized by gradual stromal thinning and astigmatism. Altered degradation of corneal extracellular matrix is a suggested etiology for this disorder. In the present study we established keratocyte cultures from normal and keratoconus corneas and investigated the roles that matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMP, TIMP-2) may play. After chemical modification (reduction and alkylation) to remove the inhibitor and activation of enzyme with p-aminophenylmercuric acetate (APMA), keratoconus-conditioned media displayed a significant increase (p < 0.05) in the total potential gelatinolytic activity when compared with normal culture media treated in a similar manner. Basal levels of gelatinolytic activity in keratoconus culture media (no reduction, alkylation, or APMA treatment), determined by two different assay methods, tended to be about twice that of normal cell cultures. By zymography, both keratoconus and normal cultures showed identical enzyme patterns, which represented MMP-2 (72 kDa) in its proform and, depending on the treatment of the media, varying amounts of activated MMP-2 (65 kDa). This suggests that the increased gelatinolytic activity in keratoconus was not correlated with an increased appearance of either the 65-kDa-activated form of MMP-2 or a new MMP species. In addition, no differences in the amount of MMP-2 were detected that could account for the increased activities in keratoconus cultures. However, a relative decline in the detectable TIMP levels in keratoconus cultures resulted in an apparent three-fold increase in the ratio of MMP-2/TIMP. Northern blots showed no significant changes in mRNA levels for MMP-1, MMP-2, MMP-3, TIMP, or TIMP-2. These data suggest that a possible alteration in the interaction between MMP-2 and TIMP may play a role in the increased gelatinolytic activity seen in keratoconus tissues.
Cornea 1994 Mar
PMID:Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio. 815 82

Gel Injection Adjustable Keratoplasty (GIAK) is a technique previously described by G. Simon for the correction of myopia. Following pachometry, a 0.8 mm wide, 80% deep linear incision is performed 2.5 mm from the apex. Using a guide, a 1 mm wide, 5 mm diameter annular spatula is introduced to dissect an interlamellar canal and the crosslinked polyethylene oxide hydrogel is injected with a modified 23 gauge needle. The biocompatibility to 13 PEO batches was studied on 21 albino rabbits (Follow up 15 to 135 days). In nineteen, the cornea remained perfectly transparent. Two animals presented an infection at POD 1. Histopathology showed no endothelial deterioration, no anomaly of the thickness or of the cellular morphology around the injected zone. However some mononuclear cells were noticed surrounding the hydrogel in some rabbits together with thinning of the corneal epithelium anterior to the injected zone. A pilot refractive study was conducted on 5 cats using 2 PEO gels. One cat developed an infection following surgery. A second developed an inflammatory response with corneal neovascularization at POD 8. Thus, these animals were not included in the follow-up study which ranged from 6 to 28 months. Immediately after surgery, the refractive effect, measured with the Canon SK-1 digital autokeratometer, was 5.22 +/- 0.46 D (SD) of flattening. The long term effect (26 months) of the GIAK procedure appears to be stable and safe when using sterile PEO gels made of highly purified materials.
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PMID:[Results of a 2-year animal experiment with reticulated polyethylene oxide intrastromal rings]. 817 89


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