Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0851184 (thinning)
 11,252 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The Hughes' tarsoconjunctival flap technique has proved to be a reliable operative procedure for the treatment of large lower-lid defects for more than 55 years. The Hughes' procedure has maintained its importance despite the development of numerous other operations, two reasons for this being that there have now been several modifications to this technique and that the lids do not have to be closed as long. To help the surgeon avoid and eliminate problems and errors in the operative technique we provide details and some useful tricks we have learned over the years while treating over 50 patients. The causes, prophylaxis, and correction of postoperative complications are described for the following: lowering the lid margin; thinning of the lid in the area of the tarsal transposition; lymph edema of the transplant; lid margin defects, and dehiscence of the wound; corneal epithelial defects; trichiasis caused by lanugo hair; keratinization of the lid margin; ectropion of the conjunctiva; retraction of the upper lid, and entropion of the upper lid. If these details are taken into consideration, the Hughes' procedure is a simple operative technique that is free of serious complications and gives good results in the reconstruction of the lower lid.
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PMID:[Tarsoconjunctival transposition. Causes, prevention and possibilities for correction of postoperative complications]. 130 7

Transscleral Nd:YAG laser cyclophotocoagulation was performed on 100 consecutive patients. A contact lens designed specifically for this operation was used, and the results were compared to those of a previously reported series of 100 patients in which the same procedure was performed without the lens. The lens provided intraoperative advantages of eyelid separation, compression and blanching of the conjunctiva at the treatment site, and precise measurements for placement of the laser applications. Early postoperative advantages were reduced conjunctival burns and less hyperemia. However, the long-term results were comparable between the two series, with the exception of a higher incidence of phthisis when the lens was used. The thinning and blanching of the conjunctiva may increase the percentage of laser energy reaching the ciliary processes, which suggests a need for reduced energy levels when using the lens.
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PMID:Transscleral Nd:YAG laser cyclophotocoagulation with a contact lens. 195 2

Focused high-intensity ultra-sound is used to treat glaucoma. Histopathologic examinations of rabbit and pig eyes following therapeutic ultrasound demonstrated highly localized lesions including destruction of the ciliary epithelium and thinning of the sclera. The bond between the sclera and the ciliary epithelium is weakened. The conjunctiva remains intact. The histologic findings in human eye enucleated after ultra-sound therapy are identical. Three mechanisms for pressure reduction are proposed: transscleral outflow of aqueous humor can occur under the overlying conjunctiva; focal destruction of the ciliary epithelium can reduce aqueous production; scleral scarring produces the potential for separation of the ciliary body and the sclera.
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PMID:[Principles and histologic effects of the treatment of hypertension with focused high-intensity ultrasound]. 223 1

Four Macaca nemestrina monkeys were inoculated in the conjunctiva with Chlamydia trachomatis (strain E) at 6 weeks of age. A fifth monkey was inoculated with HeLa cell materials only. Ten weeks later, all monkeys were reinoculated with either strain E or strain C. All inoculated monkeys were susceptible to infection with C. trachomatis as documented by fluorescent antibody staining of smears and reisolation of the organism from conjunctival and nasopharyngeal swab specimens. Rectal and vaginal swab specimens remained negative throughout the study. Three of four inoculated animals responded with IgM titers reaching a peak of 1:16 (M#3) and 1:32 (M#1, M#4) 2 weeks after the primary inoculation. IgG appeared in all inoculated animals and titers rose to peak levels of 1:64 (M#2), 1:128 (M#1, M#3), and 1:256 (M#4). Histopathology documented a dramatic difference in immunological response following secondary inoculation. Primary inoculation elicited a typical inflammatory response characterized by moderate stromal infiltration of polymorphonuclear and mononuclear leukocytes. Plasma cells appeared by week 3 postinoculation (pi). Following a secondary inoculation, classic follicle formation was evident by 1 week pi. Mononuclear markers identified a germinal center composed of B cells and a T cell cap. Epithelial thinning near the cap of the follicle was accompanied by a complete loss of goblet cells. This model may be useful for studying the immunopathology of infant chlamydial infections.
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PMID:Experimentally induced ocular chlamydial infection in infant pig-tailed macaques. 272 53

Specimens of a cornea, conjunctiva and iris were removed at the time of penetrating keratoplasty in a case of nephropathic cystinosis. Immunohistochemical studies revealed the presence of class II antigens on the stromal keratocytes of the cornea and the vascular endothelial cells, pericytes and fibroblasts of the conjunctiva. In addition, there were thinning and focal breaks in Bowman's membrane. Both of these findings may have contributed to the severe photophobia and blepharospasm seen in patients with longstanding cystinosis.
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PMID:Nephropathic cystinosis: immunohistochemical and histopathologic studies of cornea, conjunctiva and iris. 358 80

In the prospective Basel longitudinal study on aging (1955-1978) 123 men (age at entry from 6-61 years) were investigated in 2 year (average) intervals. Complete case histories are available on 67 subjects over the entire period (19.6 +/- 0.85 years). Part I of the study was to confirm the hypothesis of Bernstein and of Steinhaus, according to which life expectancy can be estimated from the speed of development of presbyopia. Parallel to the measurement of accommodation range (after preliminary determination of refraction and visual acuity), the development of height, body weight, vital capacity, expiratory volume, chest circumference, abdominal circumference, blood pressure, ECG and pulse wave velocity were measured. Invasive investigations were not undertaken. Only when hypertension was combined with obesity was the diminution of accommodation range striking (Fig. 10c; however there were only 3 subjects in this risk group). Taking everything into consideration there was a concomitance between decrease of accommodation range and changes of medical parameters (Table 6). Intercurrent illness did not influence the accommodation range. Longitudinal measurements and cross-sectional comparisons (data averaged to the same point as of the same age) were carried out. The results did not always coincide. We could not confirm the hypothesis of Bernstein and of Steinhaus. In Part II the results of the objective measurements are given. Apparently growth of the skull does not stop entirely. The increase of interpupillary distance can be complete at 17 years of age, but also can continue to the 30th year. The palpebral fissure increases an average of 3 mm more horizontally between the 6th and the 20th year of life. The corneal diameter remains constant in all age classes, that is, the growth of the cornea should be complete before the 6th year of life. Early arcus senilis changes are found already in the 20-year-old. The increase in the course of time of arcus senilis is obvious, it is most pronounced in obese hypertensives. Still there are persons who at 65 years of age show no arcus senilis. In the 20th year degenerative deposits in the conjunctiva begin. They increase in number and above the 60th year all subjects showed degenerative deposits. Aqueous veins are less visible in younger subjects. With increasing age--as a result of degenerative thinning of the conjunctiva--they are recognizable in ever greater numbers. The depth of the anterior chamber attains its greatest extent between the 20th and the 30th year.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:The Basel longitudinal study on aging (1955-1978). Ophthalmo-gerontological research results. 362 22

Controlled ultrasonic energy was used to treat a series of laboratory animals in which glaucoma had been induced experimentally. Insonification successfully reduced elevated intraocular pressure in the majority (86%) of test animals. Histopathologic review of globes examined at varying time intervals following treatment showed localized thinning of the sclera with intact conjunctiva, allowing filtration and focal disruption of ciliary epithelium. This technique of treating elevated intraocular pressure in a noninvasive manner offers potential for clinical application in humans.
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PMID:Therapeutic ultrasound in the treatment of glaucoma. I. Experimental model. 399 Nov 21

The major histopathologic changes seen in the eyes of patients undergoing bone marrow transplantation involve the conjunctiva, cornea, choroid, and lacrimal gland. The major finding in the conjunctiva is keratinization. The major findings in the cornea are epithelial thinning and keratinization. Keratinization of the conjunctiva and cornea is associated with graft-v-host disease (GVHD) and may be either a primary manifestation of GVHD or be secondary to the "dry eye" syndrome that develops in patients with GVHD. Corneal epithelial thinning is probably secondary to the chemotherapy used in the preparative regimen. An unusual histiocytelike infiltrate is present in the choroid and appears to be associated with GVHD. In acute GVHD, lacrimal gland stasis occurs and is the probable cause of the dry eyes seen in these patients.
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PMID:The eye in bone marrow transplantation. II. Histopathology. 634 Jun 49

After debridement of the entire corneal epithelium, epithelial cells of conjunctival origin cover the exposed corneal surface. Four to five weeks later, these cells undergo a morphologic transformation to normal-appearing corneal epithelium. To study this transformation the entire corneal epithelium was removed from rabbits with the use of n-heptanol, after which the histologic appearance of and the number of goblet cells in the regenerated epithelium were noted. Five stages of transformation were seen. Immediately after healing, the epithelium consisted of one to two squamous cell layers with no goblet cells apparent at the light microscope level (stage 1). In the following weeks goblet cells appeared at the limbal edge of the cornea (stage 2), reached a uniform distribution across the cornea (stage 3), and subsequently receded toward the limbus (stage 4), leaving an epithelium with normal corneal morphologic appearance (stage 5). To see if there was an ongoing centripetal cell migration from the conjunctiva across the cornea after initial healing, the central corneal epithelium was isolated from the periphery by a ring of glue. Such isolation resulted in a thinning of the central epithelium and a thickening of the peripheral epithelium. These studies suggest that (1) the transformation into corneal epithelium lags behind defect closure by 4 to 5 weeks, (2) goblet cells do not initially migrate as recognizable cells, and (3) there is a continuous centripetal cell motion even after the initial defect closure is accomplished.
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PMID:Corneal re-epithelialization from the conjunctiva. 725 Dec 97

To investigate tissue changes induced by the implantation of expanded polytetrafluoroethylene (e-PTFE) used as encircling scleral buckling, an experimental and histopathological study was performed in rabbits. The eyes of 12 rabbits were implanted during 20-128 days with e-PTFE episcleral implants. Of these, 8 eyes were uncomplicated and enabled us to perform the histopathological study, 2 others were discarded for too short a time of implantation and, in 2 additional eyes, the episcleral implant was exposed with a wide conjunctival erosion. Surrounding the implant, a constant encapsulation was combined with numerous giant cells, forming a granuloma caused by irregularities of the implant outline. Its porous structure allowed a peripheral colonization by fibrovascular tissue. Scleral thinning and scleral invagination were the main scleral changes. No change of the conjunctiva made us suspect that a granuloma occurred before it was found histologically. The granulomatous changes did not seem to modify the apparently good experimental tolerance of the material after its implantation.
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PMID:Expanded polytetrafluoroethylene episcleral implants used as encircling scleral buckling. an experimental and histopathological study. 1075 44


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