Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0849787 (nipple discharge)
 518 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We studied a series of 44 consecutive cases of male breast carcinoma over a 14 year period in order to evaluate the clinico-pathological characteristics and the impact of some morphologic factors on prognosis. The age of the patients ranged from 38 to 84 years (mean 62 +/- 10.8). All the patients presented a painless mass, associated with nipple retraction in 13 cases (29.4%), skin ulceration in 12 cases (27.2%) and nipple discharge in 6 (13.6%). Microscopically all the tumors were infiltrating ductal carcinomas, 42 being of the NOS type. A better survival was associated with low mitotic index, T 1 tumors and absence of peritumoral lymphatic permeation. However, only these two parameters had statistical significance and were found to have predictive value on the prognosis of the disease. The degree of differentiation assessed according to Bloom and Richardson's classification showed no influence on prognosis. Post surgical radiotherapy did not seem to influence the outcome of the disease.
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PMID:Morphology of male breast carcinoma in the evaluation of prognosis. 196 31

The breast pathology files at the Institut Gustave-Russy in Villejuif, France, were searched for papillary cystadenomas and papillary carcinomas diagnosed between January 1, 1960, and December 31, 1974. A total of 158 cases were selected for this study; they were subclassified into 74 papillary cystadenomas, 63 papillary carcinomas, and 21 multiple papillomas. Spontaneous nipple discharge was the primary reason for consultation in 88% of solitary cystadenoma patients, 48% of multiple papilloma patients, and 23% of the carcinoma patients. The data support the benign nature of papillary cystadenoma inasmuch as none of the 73 patients treated with local excision developed cancer of the same breast, with only one patient having recurrence of the lesion. In contrast, multiple papilloma was associated with a high recurrence rate and malignant transformation. According to Scarff and Bloom's grading system, papillary carcinoma was found to be of low grade malignancy with a five-year survival rate of over 90%.
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PMID:Papillary tumors of large lactiferous ducts. 719