Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0849640 (
skin damage
)
1,516
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The level of sun ultraviolet ray reaching the surface of the earth is increasing severely due to the rapid development of the society and environmental destruction. Excessive exposure to ultraviolet radiation causes
skin damage
and photoaging. Therefore, it is emerged to develop effective sunscreen to prevent ultraviolet-induced
skin damage
. This study was aimed at investigating the effects of Coenzyme Q
10
(CoQ
10
) sunscreen on the prevention of ultraviolet B radiation- (UVB-) induced mouse
skin damage
. Three-month-old female mice were used, and they were randomly divided into four groups: control, model, CoQ
10
, and titanium dioxide (TiO
2
; positive control) groups. Our results showed that body weight, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and
DNA (cytosine-5)-methyltransferase 1
(DNMT1) protein expression were significantly decreased, while malondialdehyde (MDA) activity and metalloproteinase-1 (MMP-1) level were increased in UVB-treated mice. Besides, the stratum corneum was shed from the skin surface in the model group compared with the control group. In contrast, CoQ10 sunscreen prevented from UVB-induced
skin damage
, as well as reversing SOD, GSH-Px, and MDA activities, and MMP-1 and DNMT1 levels. Taken together, the current study provided further evidence on the prevention of UVB-induced
skin damage
by CoQ
10
and its underlying mechanisms.
...
PMID:Coenzyme Q
10
Sunscreen Prevents Progression of Ultraviolet-Induced Skin Damage in Mice. 3292 87
