Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0849640 (
skin damage
)
1,516
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Atmospheric particulate matter (PM) is an important cause of
skin damage
, and an increasing number of studies have been conducted to discover safe, natural materials that can alleviate the oxidative stress and inflammation caused by PM. It has been previously shown that the extract of
Ecklonia cava
Kjellman, a perennial brown macroalga, can alleviate oxidative stress in epidermal keratinocytes exposed to PM less than 10 microns in diameter (PM10). The present study was undertaken to further examine the anti-inflammatory effects of
E. cava
extract and its major polyphenolic constituent, dieckol. HaCaT keratinocytes were exposed to PM10 in the presence or absence of
E. cava
extract or dieckol and analyzed for their viability, prostaglandin E
2
(PGE
2
) release, and gene expression of cyclooxygenase (COX)-1, COX-2, microsomal prostaglandin E
2
synthase (mPGES)-1, mPGES-2, and cytosolic prostaglandin E
2
synthase (cPGES). PM10 treatment decreased cell viability and increased the production of PGE
2
, and these changes were partially abrogated by
E. cava
extract.
E. cava
extract also attenuated the expression of COX-1, COX-2, and mPGES-2 stimulated by PM10. Dieckol attenuated PGE
2
production and the gene expression of COX-1, COX-2, and
mPGES-1
stimulated by PM10. This study demonstrates that
E. cava
extract and dieckol alleviate airborne PM10-induced PGE
2
production in keratinocytes through the inhibition of gene expression of COX-1, COX-2,
mPGES-1
, and/or mPGES-2. Thus,
E. cava
extract and dieckol are potentially useful natural cosmetic ingredients for counteracting the pro-inflammatory effects of airborne PM.
...
PMID:Marine Alga
Ecklonia cava
Extract and Dieckol Attenuate Prostaglandin E
2
Production in HaCaT Keratinocytes Exposed to Airborne Particulate Matter. 3123 5
