Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0849640 (skin damage)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to search for radical scavengers which could be used as raw materials for cosmetics, phenyl propanoids (eugenol, isoeugenol, dehydrodieugenol, dehydrodieugenol B and coniferyl aldehyde) were examined for their hydroxyl radical (.OH) scavenging ability. A Fenton system was used to produce .OH. In order to see scavenging by these phenyl propanoids, competition reactions between a spin trap, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), and these phenyl propanoids for .OH were studied. The relative yield of the spin adduct of .OH (DMPO-OH) was measured by electron spin resonance spectroscopy. The approximate rate constants of the reactions between these phenyl propanoids and .OH estimated by measuring the reduced height of the ESR signals of DMPO-OH were found to be at least in the order of 10(9) M-1 s-1 (diffusion-controlled). Also, using the TBA tests, the reactions between .OH and several compounds reactive with .OH were investigated in the presence of the phenyl propanoids and it was found that the phenyl propanoids compete with such reactive compounds for .OH. These results indicate that these phenyl propanoids can be used as antioxidants for skin damage perhaps caused by .OH generated by UV-light.
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PMID:Essential oil phenyl propanoids. Useful as .OH scavengers? 131 53

Oxymethyluracil (OMU) ointment stimulated reparative regeneration of skin in white mongrel rats with model skin damage. The efficacy of this preparation is higher than that of methyluracil-containing ointments (especially of the gel-based preparation). Simultaneous oral administration of OMU potentiated the efficacy of the ointment. After oral administratrion, OMU was found in the wound OMU decreases the level of malonic aldehyde in the blood of rats with model wounds, while not changing the level of nitrogen oxide. In the test group treated with OMU ointment, the biomechanical characteristics of cicatrix after wound healing are closer to the characteristics of intact skin than in the untreated control group.
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PMID:[Oxymethyluracil stimulates reparative regeneration of skin in rats]. 1555 41