Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0849640 (skin damage)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mouse legs were irradiated with a dose of 30 Gy. After 50 days, when the acute reaction had regressed to a steady state, they were retreated with either 30 Gy of X rays delivered in six fractions over 12 days, six exposures to hyperthermia for 45 min at 42.7 degrees C, six doses of cis-DDP, or a combination of these agents. The maximum skin reactions and the skin reactions integrated over 50 days were determined. The maximum skin response was found when the previously irradiated skin was treated with a combination of X irradiation and hyperthermia. The addition of cis-DDP to this regimen did not result in a further enhancement of the skin reaction. When the second treatment was irradiation alone or cis-DDP alone, the severity of the skin reactions was similar. Injury from the initial radiation dose persisted so that the cytotoxic action of cis-DDP resulted in a level of subacute skin damage that was similar to a second course of X irradiation.
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PMID:The response of previously irradiated skin to combinations of fractionated X radiation, hyperthermia, and cis-diamminedichloroplatinum. 653 84

Combating multidrug resistance (MDR) of tumors is still challenging for clinical chemotherapy, cocktail chemotherapy (CCT), and currently widely-studied nanodrug-based treatments. Inspired by different MDR-overcoming and antitumor mechanisms of CCT and photothermal therapy (PT), a dual drug-paired polyprodrug nanoparticle (PDCN25-CDDP) was constructed to achieve the combination therapy PT-CCT for reversing MDR and combating multidrug resistant cancers. The PT-CCT treatment can greatly downregulate the P-gp expression level and achieve utmost MDR-reversal and antitumor efficacy by both a cocktail effect of CCT and a synergistic effect of CCT with PT; meanwhile, PT can inhibit the expression of heat shock protein 90 and enhance the thermosensitivity of cancer cells. Upon NIR irradiation, PDCN25-CDDPin vivo produced a selective tumor accumulation effect and relatively deep tumor penetration, as evidenced by fluorescent and photoacoustic imaging and CLSM. The mild PT-CCT treatment completely eradicated MCF-7/ADR and OVCAR-3/DDP tumors without skin damage or tumor recurrence for 30 days, exhibiting synergistic MDR-reversal and superior antitumor efficacy in vivo. Importantly, this work provides an innovative strategy for reversing MDR and combating DOX-resistant breast and CDDP-resistant ovarian cancers.
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PMID:Dual drug-paired polyprodrug nanotheranostics reverse multidrug resistant cancers via mild photothermal-cocktail chemotherapy. 3141 Dec 35