Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0849640 (skin damage)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retention suture using the buried technique has been developed. This retention suture encompasses fascia, muscle and subcutaneous tissue and remains extraperitoneally and just below the skin. Since the suture material is not in contact with the skin, complications, such as skin damage, stich abscesses and infection at exit points, are avoided. Severe postoperative pain related to retention sutures is minimized.
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PMID:Placement of retention sutures. 32 44

Pain and detection thresholds upon Nd:YAG laser irradiation were studied in healthy human subjects. The output power was set at 100 mW (1.36 W/cm2), 300 mW (4.11 W/cm2), 600 mW (8.22 W/cm2), 800 mW (11.0 W/cm2) and 1,000 mW (13.7 W/cm2). The duration was 5 seconds. The irradiation was done to the hand dorsum using the non-contact method (distance between the subject and the laser tip was 5.0 mm). After irradiation, the detection threshold was about 600 mW and the pain threshold was about 1,000 mW. The skin temperature was 34.9 +/- 0.64 degrees C before irradiation and 38.0 +/- 0.45 degrees C after a 5-sec-irradiation at 1,000 mW. No skin damage was observed after the irradiations.
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PMID:[Sensory responses to Nd:YAG laser irradiation in humans]. 213 30

Primary afferent units in the saphenous nerve of cats, functionally identified as A-delta myelinated nociceptors, were tested for their responses to stimulation of the sympathetic trunk. The units were subdivided functionally into A-mechano-heat receptors (AMHs), which respond to both noxious heat and pressure, and high-threshold mechanoreceptors (HTMs), which respond only to pressure. No units of either subdivision were activated by sympathetic stimulation (SS) prior to noxious heating of their receptive fields. However, six of the seven AMH units with the highest mechanical thresholds (greater than 5 g von Frey) were activated by SS alone (10 Hz) after they had been sensitized by noxious heating of their receptive fields. Sensitized AMH units with lower mechanical thresholds (less than 5 g) were generally not activated by SS alone (1 of 22 units), and their responses to warming of their receptive fields were not altered by SS. The excitatory sympathetic action on AMH units was abolished by alpha- but not beta-andrenergic blockade in the two units tested. HTMs were unresponsive to SS even after repeated noxious heating of their receptive fields (15 units tested). The results of this study indicate that relatively high rates of sympathetic efferent activity (10 Hz) can induce firing in a small population of AMH receptors in damaged skin, specifically those units with high mechanical thresholds. This sympathetically evoked activity might trigger or exacerbate pain associated with skin damage; however, functional conclusions are difficult to draw, because of the scarcity of such units and the fact that the responses in some were brief and of low firing rates.
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PMID:Sympathetic activation of A-delta nociceptors. 299 42

A chemical operator handling dimethyl acetylenedicarboxylate (DMAD) developed delayed and pain-free burns on one of his feet 2 days after a supposed spillage of DMAD. The injuries were confirmed to be associated with DMAD by chemical analysis of the operator's safety boot and patch tests. DMAD easily penetrates some protective clothing and dilute solutions can still be hazardous: the toxic effect is compounded by being delayed and painless. The lachrymatory irritant properties of undiluted DMAD are not adequate warning of its presence or spillage in quantities sufficient to cause significant skin damage.
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PMID:Delayed dermal burns caused by dimethyl acetylenedicarboxylate. 623 90

The dimensions and healing of 93 consecutive below-knee stumps were studied and based on observations a standard formula of stump classification was constructed (and discussed at the ISPO Meeting in Bologna 1980). Muscular atrophy and redistribution of oedema caused a mean reduction of calculated arbitrary stump volume of about 7% during the first 12 post-operative weeks accompanied by a change in distal circumferential measurement ranging between 7 centimetres reduction and 5 centimetres increase. The classification formula was tested in 135 examinations in 86 patients with 96 stumps in Lund. A new proportional definition of stump length was used. Eighty per cent were ordinary in length and shape. Ten of 59 were conical before one year compared to 12 of 42 after more than one year following amputation. Pain was a problem in 20%. Scar problems are common early but other skin damage increases with time. Skin problems are separated according to cause, i.e. pressure, suction, infection and allergy. One third of below-knee stumps had unhealed wound or damaged skin. Surgical correction was indicated in 2% and prosthetic correction in 7%. Prosthetic correction seemed to be more often needed in below-knee stumps and surgical correction in above-knee stumps.
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PMID:A clinical standard of stump measurement and classification in lower limb amputees. 685 47

Neurophysiological and behavioural observations in animals suggest that sympathetic neural activity and noradrenaline have an excitatory effect on nociceptor discharge in inflamed skin. To determine whether noradrenaline influences pain sensations in humans, heat hyperalgesia in forearm skin sensitized by topical application of 0.6% capsaicin was measured at sites of noradrenaline or saline ionophoresis in 10 healthy subjects. At control sites and sites of saline ionophoresis heat hyperalgesia decreased over the course of the experiment as inflammation subsided. In contrast, heat hyperalgesia persisted at sites of noradrenaline ionophoresis. These findings are consistent with neurophysiological observations that noradrenaline and sympathetic neural stimulation increase nociceptor discharge in inflamed skin, and suggest that sympathetic neural activity might increase pain associated with skin damage.
Pain 1995 Mar
PMID:Noradrenaline increases hyperalgesia to heat in skin sensitized by capsaicin. 759 27

The feasibility of iontophoretic transdermal delivery of tranilast (N-(3,4-dimethoxycinnamoyl) anthranilic acid) for the treatment of keloid and hypertrophic scars was evaluated in hairless rats and humans. A drug electrode containing tranilast 1.5 ml (8 mg/ml in ethanol/water (8/2, v/v) mixture) was placed on the dorsal skin surface of anaesthetised rats or the affected parts of patients, and connected to the negative pole; an electric current (0.5-4 mA for rats, 2 mA for people) was pulsed through at one minute intervals. Tranilast was effectively delivered transdermally iontophoretically into the restricted skin tissues of hairless rats and the affected parts of four patients with hypertrophic scars with no skin damage. In four other patients tranilast given iontophoretically for a period of 30 minutes a week reduced the patients' complaints of pain and itching after only one or two treatments although there were some variations among patients. These results indicate that the transdermal iontophoretic delivery of tranilast is a useful treatment for keloid and hypertrophic scars, particularly for relieving pain and itching, and is more beneficial than tranilast given orally.
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PMID:Treatment of keloid and hypertrophic scars by iontophoretic transdermal delivery of tranilast. 923

Hot air burns resulting from hairdriers held against the skin are rare. The largest published clinical series relates to burns in children injured by the use of hairdriers at home. Adults are assumed not to be at risk because the pain associated with thermal injury would normally stimulate acute action to prevent further skin damage. We present two adult patients in whom the normal protective mechanisms were inactive. There was loss of consciousness resulting from an epileptic fit in one case, and the local absence of sensation in a flap used to reconstruct a breast after mastectomy, in the other. The temperatures generated by hairdriers were experimentally assessed and the results are reviewed. We emphasize that hairdriers are a potentially dangerous source of hot air and can cause burns.
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PMID:No sense; no sensibility--a tale of two adult hairdrier burns. 942 19

The response to tissue injury includes sensitization of peripheral nociceptors and central neuronal pathways leading to acute clinical and inflammatory pain. A further response is sprouting of sensory nerve terminals in the region of skin damage. This hyperinnervation response is particularly intense in neonates compared with adults. In this study, we tested the effect of regional nerve block at the time of injury on skin hyperinnervation. Anaesthetized newborn rat pups were treated with percutaneous sciatic nerve block injections of 0.25% bupivacaine 25 microliters followed by a localized hindpaw skin wound. Cutaneous innervation was studied by image analysis of immunostained skin sections, 7 days after wounding, and sensory thresholds were assessed using von Frey hairs. The results showed that both hyperinnervation and hypersensitivity were not significantly altered by the application of a regional nerve block at the time of injury. This suggests that regional analgesia, used commonly in clinical practice, is unlikely to prevent the hyperinnervation that follows skin wounding.
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PMID:Sensory hyperinnervation after neonatal skin wounding: effect of bupivacaine sciatic nerve block. 1067 89

(1) Iloprost, a vasodilatory prostacyclin analogue administered by infusion, is indicated for second-line therapy in patients with severe ischaemia of the lower limbs, when surgical revascularisation fails or is contraindicated. (2) In thromboangiitis obliterans the clinical file on iloprost has remained inadequate since the product was first released. (3) A meta-analysis of 6 clinical trials giving conflicting results in patients with stage III or IV lower-limb arterial disease favoured iloprost. But the results of this meta-analysis are uninterpretable because of methodological biases. It is not known what effects iloprost has in the short term (on pain and skin damage) or in the long term (on the risk of amputation). (4) The iloprost dose must be adjusted individually according to adverse effects linked to vasodilation.
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PMID:Iloprost: new indication. Not adequately assessed. 1084 61


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