Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0849640 (skin damage)
 1,516 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HSCT provides the opportunity to replace a damaged tissue. It is the most important treatment for high risk hematologic malignant and non malignant disorders. An important challenge in the identification of matched donors/patients is the HLA diversity. The Mexican Bone Marrow Registry (DONORMO) has nowadays > 5000 donors. The prevalent alleles are Amerindian, Mediterranean (Semitic and Spanish genes) and African. In theory, it is possible to find 11% of 6/6 A-B-DR low resolution matches for 70% of patients with Mexican ancestry. We contributed with 39 unrelated, cord blood and autologous HSCT for patients with malignant, genetic and autoimmune disorders. Overall disease survival was 50% (2-7 years) depending on the initial diagnosis, conditioning, disease evolution or other factors. Clinical studies using autologous and unrelated HSC are performed on patients with refractory autoimmune diseases producing mixed results: mainly, T1D, RA, MS, SLE. Improvement has been observed in skin damage and quality of life in SLE and systemic sclerosis. Disease stabilization in 2/3 of MS patients. However, in RA and T1D, initial benefits have been followed by eventual relapse. With growing clinical experience and protocol improvement, treatment-related mortality is decreasing. Proof efficacy will be achieved by comparing HSCT with standard therapy in autoimmunity.
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PMID:Hematopoietic stem cell transplantation (HSCT): an approach to autoimmunity. 1648 16

To determine if skin damage is related to disease duration in Brazilian patients with SLE followed in a tertiary reference center through the application of standardized damage index (SLICC/ACR-DI). Sixty SLE patients were enrolled in this study. Relevant data were obtained through patients' interview, physical and laboratory examinations and review of the hospital records. The frequency and the different types of organ damage were determined using de SLICC/ACR-DI. Statistics were performed through chi-square and Student's t tests. Multivariate regression was used to correlate damage with disease duration. Forty-one (68.3%) patients presented any type of cumulative organ damage. The skin (35%), renal (23.3%) and neuropsychiatric (18.3%) systems were the most frequently involved, followed by peripheric vascular, ocular and cardiovascular systems. Non-Caucasoid patients and patients with longer disease duration had a slight tendency for greater organ damage (P = 0.05). Skin damage occurred independently of disease duration, whereas cardiovascular (P = 0.051), peripheral vascular (P = 0.057) and pulmonary damage (P = 0.06) had a tendency to occur more frequently in patients with longer disease duration. In this study, 68.3% of permanent damage was observed. An elevated frequency of skin damage was observed in this population which occurred independently of disease duration. Non-Caucasian patients had a tendency to present higher scores, but more studies are necessary to determine if ethnic or economic factors are involved.
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PMID:Skin damage occurs early in systemic lupus erythematosus and independently of disease duration in Brazilian patients. 1703 32