Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0848771 (neurological disability)
 928 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

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Human Gene/Protein
KLHL13 11.7
SH3BP4 11.7
2',3'-cyclic nucleotide 3' phosphodiesterase 11.6
protein tyrosine phosphatase receptor type C 11.6
HSPA4L 11.5
NEXN 11.4
HARS2 11.1
RRN3 10.8
N-acetylglucosamine-6-O-sulfotransferase 10.8
EPB41L4A 10.7
tetraspan membrane protein 10.7
LARS2 10.5
DNAJC12 10.4
Po protein 10.4
POLR1D 10.4
sphingomyelin synthase 1 10.4
ST3GAL5 10.1
SOS-1 10.1
14-3-3 epsilon protein 10.1
TMEM119 10.0
RPL3 10.0
CENPJ 10.0
ITPR3 10.0
hematopoietic prostaglandin D synthase 9.9
HSPH1 9.9
syntaphilin 9.9
betaine homocysteine methyltransferase 9.8
PEX12 9.8
C10orf2 9.7
neuronal pentraxin 1 9.7
neurofilament light protein 9.7
DPPX 9.7
LRP130 9.6
MOBP 9.5
cystatin D 9.5
COMT protein 9.5
HSP70B 9.5
CLPP 9.0
HLA-DRB1*15 9.0
Glypican-5 9.0
CDK5RAP2 9.0
PTRF 9.0
CNR2 8.9
LRPPRC 8.9
UCP4 8.9
UCP5 8.9
HSPA6 8.8
TUBA1A 8.7
P2RY12 8.7
VAV1 8.6
DRB1* 8.6
CRASH 8.5
KLK6 8.5
TRKB 8.5
ataxin-7 8.4
MOG 8.4
GP130 8.4
Frataxin 8.4
KLK2 8.4
KLK1 8.2
VDB 8.1
Tissue kallikrein 8.1
Spinocerebellar ataxia type 7 8.1
mGlu3 8.0
QKI 8.0
BACH1 7.9
GM3 synthase 7.9
MCPH1 7.9
HSD17B4 7.8
Caspr2 7.8
AAAS 7.8
S-adenosyl-L-homocysteine hydrolase 7.8
AXIN1 7.8
HSP90AA1 7.8
PSN 7.7
nuclear respiratory factor-1 7.7
ASPM 7.7
CEBPB 7.7
cell adhesion molecule L1 7.7
CNR1 7.6
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Disease
Multidirectional nystagmus 15.1
Tumorlet 13.1
Progressive multiple sclerosis 12.5
Secondary progressive multiple sclerosis 11.6
Adhesive arachnoiditis 11.6
Spinal cord atrophy 11.5
Retinal atrophy 11.3
Demyelinating disorders 10.7
Progressive myoclonic epilepsy 10.7
Hypoxic-ischemic brain injury 10.7
Primary progressive multiple sclerosis 10.3
triplegia 10.2
Acute posterior multifocal placoid pigment epitheliopathy 10.2
Intermediate uveitis 10.1
Cryptococcal infections 10.1
Reversible posterior leukoencephalopathy syndrome 10.0
Neonatal meningitis 10.0
Cavernous sinus thrombosis 9.9
Balo's concentric sclerosis 9.8
Cervical myelopathy 9.7
secondary cardiomyopathy 9.6
maternal alcoholism 9.6
Relapsing-remitting multiple sclerosis 9.6
Neonatal encephalopathy 9.5
CNS demyelinating disease 9.0
Chronic inflammatory demyelinating polyradiculoneuropathy 8.8
polioencephalomyelitis 8.7
Hypoxic-ischemic encephalopathy (HIE) 8.7
Tuberculous meningitis 8.6
diffuse sclerosis 8.4
pars planitis 8.4
cerebrovascular occlusion 8.3
Neuromyelitis optica 8.3
multiple sclerosis 8.3
Osteoradionecrosis 8.1
Spinal epidural abscess 8.1
CMT1A 8.0
MCPH1 8.0
Ischemic stroke 8.0
leukoencephalitis 7.9
optic neuritis 7.9
Periventricular leukomalacia 7.8
traumatic coma 7.8
periphlebitis 7.8
Adie 7.8
myelomalacia 7.8
PSN 7.7
hereditary motor and sensory neuropathy 7.6
Toxoplasma encephalitis 7.6
Bielschowsky 7.5
pansinusitis 7.5
global aphasia 7.5
Insulinoma 7.4
Middle cerebral artery occlusion 7.4
polyradiculoneuropathy 7.4
encephalomyelitis 7.3
ranula 7.3
GM2 gangliosidosis 7.2
Acute disseminated encephalomyelitis 7.2
IDD 7.1
panuveitis 7.1
AHL 7.0
reactive depression 7.0
AMN 7.0
hemichorea 6.9
disabling disease 6.9
memory disorder 6.9
myelitis 6.8
papillitis 6.8
cervical spondylosis 6.7
OPA1 6.7
subacute sclerosing panencephalitis 6.6
Friedreich's ataxia 6.6
congenital infection 6.6
ALD 6.5
MSS 6.5
Zellweger syndrome 6.4
Multiple system atrophy 6.4
spinal cord compression 6.3
Refsum disease 6.3
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Symptom
neurological disability 15.1
meningism 7.7
Neurologic symptoms 7.5
athetosis 7.0
loss of taste 6.5
functional recovery 6.0
halitosis 5.9
dysarthria 5.8
drooling 5.7
exertional angina 5.5
spasticity 5.4
incoordination 5.3
cerebellar ataxia 5.2
paraparesis 5.2
hemiplegia 5.1
muscle rigidity 5.0
hypothermia 5.0
myoclonus 4.6
photophobia 4.4
ophthalmoplegia 4.4
dystonia 4.3
neck pain 4.1
ataxia 4.1
Depressive symptoms 4.1
chorea 4.0
bradykinesia 3.9
spasm 3.8
weakness 3.7
seizures 3.5
fatigue 3.3
tremor 3.2
headache 3.1
thinning 2.6
paresis 2.6
nausea 2.5
agitation 2.5
stigma 2.4
hypercapnia 2.1
distraction 1.9
nausea and vomiting 1.8
dizziness 1.8
insomnia 1.7
cough 1.5
back pain 1.5
vomiting 1.1
pain 1.1
anesthesia 0.9
respiratory distress 0.8
discomfort 0.6
discomfort 0.5
overweight 0.4
analgesia 0.3
collapse 0.3
Drug
Interferon beta-1a 10.0
Ocrelizumab 9.7
Zinc acetate 9.5
Avonex 9.5
Copaxone 8.8
Novantrone 8.4
Isoprinosine 8.3
Natalizumab 8.1
Diamox 7.8
Sinemet 7.3
Pirfenidone 7.2
Sinemet 7.2
Levosimendan 6.8
Felodipine 6.5
Tocilizumab 6.3
CVA 6.2
Sinemet 6.0
Urokinase 5.8
Campath 5.5
Campath 5.5
Rosiglitazone 5.4
Methylprednisolone 5.2
Isoniazid 5.1
Prednisone 5.1
Posture 4.7
Rituximab 4.6
p75 4.1
Check 4.1
Theophylline 4.1
Frontal 4.1
-deoxyadenosine 4.0
Portal 4.0
uPA 4.0
CSF 4.0
Fragment 3.9
TAT 3.8
Nitric Oxide 3.7
IFN-beta 3.5
Vitamin E 3.4
Fluorescein 3.2
ROC 2.1
vitamin E 2.0
IFN-gamma 1.2
lysine 0.8
NADH 0.6
Dial 0.2
Cardiovasc -2.5
Enzyme
GalNAc-T 8.3
GM3 synthase 7.3
NCP 7.1
esterase D 7.1
S-adenosyl-L-homocysteine hydrolase 7.0
DMT 6.1
isopeptidase 5.9
phenylalanine hydroxylase 5.6
gamma-glutamylcysteine synthetase 5.6
GAS 5.2
nucleotidase 5.1
tissue plasminogen activator 4.8
acyl-CoA synthetase 4.7
indoleamine 2,3-dioxygenase 4.6
3-hydroxy-3-methylglutaryl coenzyme A reductase 4.6
aconitase 4.3
botulinum neurotoxin 4.2
PDK1 3.9
matrix metalloproteinase 2 3.9
TAT 3.8
ceruloplasmin 3.8
succinate dehydrogenase 3.7
demethylase 3.6
carboxylesterase 3.5
isocitrate dehydrogenase 3.5
thyroid peroxidase 3.5
CPT 3.4
GSK 3.3
MMP-3 3.3
isocitrate dehydrogenase 3.3
CPT 3.3
enolase 3.2
caspase-9 3.2
MMP 3.0
cytochrome oxidase 3.0
complex I 2.9
CPT 2.9
MIP 2.8
tyrosine hydroxylase 2.8
glutamine synthetase 2.8
adenosine deaminase 2.7
adenosine deaminase 2.7
pyruvate kinase 2.7
urokinase-type plasminogen activator 2.7
pyruvate dehydrogenase 2.6
phosphoinositide 3-kinase 2.5
caspase-3 2.5
kallikrein 2.5
AMPK 2.4
ATP synthase 2.3
NOS 2.2
gamma-glutamyl transpeptidase 1.9
lactate dehydrogenase 1.8
superoxide dismutase 1.8
AMPK 1.5
AMP-activated protein kinase 1.4
PARP 1.3
focal adhesion kinase 1.2
NO synthase 1.1
mitogen-activated protein kinase 1.1
DNA polymerase 1.0
calcineurin 1.0
collagenase 0.9
phosphodiesterase 0.9
luciferase 0.8
glutathione peroxidase 0.6
protein kinase 0.3
ERK 0.1
peroxidase 0.1
RNA polymerase -0.0
Compound
Melarsoprol 9.7
hexacosanoic acid 9.3
Zinc acetate 9.3
Cuprizone 9.2
NDS 8.3
Mitoxantrone 7.8
Mitoxantrone 7.7
DCI 7.2
Nisoldipine 7.1
Triptolide 7.1
Ethambutol 6.9
Edaravone 6.7
Quinolinic acid 6.6
DEG 6.4
Tumor Necrosis Factor 6.3
Phenoxybenzamine 6.3
DMT 6.1
DMT 6.0
Toluidine blue 5.8
Nicardipine 5.8
HMF 5.7
HPT 5.6
Nimodipine 5.5
GD3 5.5
Uridine 5.4
SAH 5.4
PLP 5.4
PMS 5.4
Methylprednisolone 5.3
Acetazolamide 5.3
Evans Blue 5.3
Minocycline 5.2
Eosin 5.1
Wellcome 5.0
N-acetylaspartate 5.0
Dipyridamole 4.9
Dipyridamole 4.9
Dipyridamole 4.9
Dipyridamole 4.9
Glycogen synthase 4.9
Eosin 4.8
MK801 4.8
PEA 4.7
Acetone 4.6
DPA 4.5
DPA 4.5
DPA 4.5
DPA 4.5
DPA 4.5
Prednisone 4.4
Biotin 4.3
GM2 4.3
MMA 4.3
Methionine 4.1
neopterin 4.1
GM3 4.0
Resveratrol 3.9
ASC 3.9
SEE 3.8
Hematoxylin 3.7
Malondialdehyde 3.7
CIT 3.7
S-adenosylhomocysteine 3.6
Theophylline 3.6
Neuronal 3.6
MCA 3.5
MCA 3.5
COX 3.5
CPT 3.4
Quercetin 3.4
5-hydroxytryptophan 3.4
Melatonin 3.4
CPT 3.3
INH 3.3
Tamoxifen 3.3
Tamoxifen 3.2
A 3 3.2
THE 3.1
Vitamin E 3.1
Retard 3.0
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