Gene/Protein
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Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Drug
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Target Concepts:
Gene/Protein
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Query: UMLS:C0848771 (
neurological disability
)
928
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In addition to maintaining immune tolerance, FOXP3
+
regulatory T (T
reg
) cells perform specialized functions in tissue homeostasis and remodelling
1,2
. However, the characteristics and functions of brain T
reg
cells are not well understood because there is a low number of T
reg
cells in the brain under normal conditions. Here we show that there is massive accumulation of T
reg
cells in the mouse brain after ischaemic stroke, and this potentiates neurological recovery during the chronic phase of ischaemic brain injury. Although brain T
reg
cells are similar to T
reg
cells in other tissues such as visceral adipose tissue and muscle
3-5
, they are apparently distinct and express unique genes related to the nervous system including Htr7, which encodes the
serotonin receptor
5-HT
7
. The amplification of brain T
reg
cells is dependent on interleukin (IL)-2, IL-33, serotonin and T cell receptor recognition, and infiltration into the brain is driven by the chemokines CCL1 and CCL20. Brain T
reg
cells suppress neurotoxic astrogliosis by producing amphiregulin, a low-affinity epidermal growth factor receptor (EGFR) ligand. Stroke is a leading cause of
neurological disability
, and there are currently few effective recovery methods other than rehabilitation during the chronic phase. Our findings suggest that T
reg
cells and their products may provide therapeutic opportunities for neuronal protection against stroke and neuroinflammatory diseases.
...
PMID:Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. 3060 86
