Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848771 (neurological disability)
 928 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Analysis of nine randomised controlled trials of prophylactic vitamin E supplementation in very low-birthweight infants (less than 1500g) showed no statistically significant reduction in the incidence of acute retinopathy of prematurity. There was a significant reduction (49 per cent) in the incidence of intraventricular haemorrhage, but no clear evidence for a corresponding reduction in intracerebral haemorrhage and no reduction in the incidence of haemorrhage confined to the germinal matrix. By combining the estimated reduction with the known incidence of long-term neurological disability associated with intracranial haemorrhage alone, it was shown that only 1.5 per cent (point estimate) and not more than about 4 per cent of all very low-birthweight infants are likely to benefit from routine vitamin E supplementation. In view of this, and data suggesting toxicity of vitamin E at concentrations close to those considered therapeutic, the routine use of vitamin E in very low-birthweight infants is not justified on present evidence. Only large randomised trials can establish whether currently used vitamin E preparations do more good than harm.
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PMID:Is routine vitamin E administration justified in very low-birthweight infants? 219 90

Evidence has accumulated that vitamin E is essential for normal neurological function. It is a fat-soluble vitamin, and, therefore, deficiency states are most likely to occur in patients with fat malabsorption. If such patients have low serum vitamin E concentrations, it is important to initiate appropriate vitamin E therapy with the aim of restoring and maintaining normal serum vitamin E concentrations and preventing long-term neurological disability. This is likely to become a more frequent problem with the increasing survival of patients with chronic fat malabsorptive states. As a corollary, it would also seem reasonable to measure serum vitamin E concentrations in all patients with spinocerebellar disorders, whatever the supposed cause.
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PMID:Use of vitamin E for prevention and treatment of spinocerebellar disorders. 685 66