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Query: UMLS:C0848676 (male subfertility)
 265 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Varicocele is the most common surgically correctable cause of male subfertility. The incidence of varicocele is about the same in adolescents as in men (16.3%). Percutaneous transfemoral sclerotherapy has been performed in 42 of the authors' own cases; it is an alternative to surgical ligation of the varicocele and should be recommended whenever a varicocele is found, to prevent gonadotoxic damage.
Urologe A 1992 Sep
PMID:[Varicocele in childhood. Treatment indications and value of sclerotherapy]. 130 10

In order to define the usefulness of subzonal sperm insertion (SUZI) and intracytoplasmic sperm injection (ICSI), we studied in a comparative trial 46 consecutive treatment cycles of microassisted fertilisation by SUZI and ICSI. By ICSI 9% of the oocytes in metaphase II were damaged in 26 treatment cycles, by SUZI, however, not one single egg in 20 cycles (p < 0.001). Fertilisation rate after ICSI (65%) was, particularly in cases with combined sperm defects as well, significantly higher than after SUZI (35%; p < 0.001). Additionally, after ICSI a higher transfer (100% vs. 75%; p < 0.05) and pregnancy rate could be obtained (38% vs. 10% per cycle; p < or = 0.05). At the moment, 3 healthy children are born (2 after SUZI, 1 after ICSI), 4 patients are in the 2nd and 3rd trimenon, respectively, the remaining 5 patients aborted. In conclusion, the ICSI technique yields better results than SUZI, especially in cases of very severe male subfertility.
Geburtshilfe Frauenheilkd 1995 Sep
PMID:[Intracytoplasmic versus subzonal spermatozoa injection. A comparison of 2 different methods of micro-assisted fertilization]. 749 21

Morphology of the spermatozoa is one of the major criteria in severe male subfertility. We report on a case of severe Oligoasthenoteratozoospermia in which a triplet pregnancy could be achieved after intracytoplasmic sperm injection (ICSI). After treatment with GnRH-analogues/HMG/HCG seven oocytes of metaphase II could be retrieved and injected. Three of them fertilised and were transferred as four-cell stage embryos after two days. Seven weeks later an intact triplet pregnancy could be detected by ultrasonography. The severe sperm defects in this case were evaluated with the technique of electron microscopy. Ultramorphology of spermatozoa appears to have an important predictive value for fertilisation and pregnancy in classical IVF. Its value for the assisted procreation techniques such as ICSI remains to be investigated.
Geburtshilfe Frauenheilkd 1995 Sep
PMID:[Triplet pregnancy after intracytoplasmic sperm injections]. 749 23

Major principles of genetic failures, chromosomal alterations and the most common syndromes associated with male subfertility should be taken into account before medical therapy and sophisticated techniques of assisted fertilization are applied to help a couple conceive. This review addresses the most common genetic reasons for male subfertility or infertility with special regard to the importance for the clinical work-up in daily routine and the potential risks for the conceptus.
Hum Reprod 1999 Sep
PMID:Genetics of male subfertility: consequences for the clinical work-up. 1057 22

Analysis of associations between testicular cancer, subfertility and offspring sex ratio (proportion of males born among newborns) was performed on 3530 Danish men, born 1945-1980, who developed testicular cancer in the period 1960-1993. As the basis of comparison we used the total population of Danish men born in the period 1945-1980 (n = 1 488 957) and their biological children (n = 1 250 989). Men who developed testicular cancer had, prior to the cancer diagnosis, a reduced fertility (standardized fertility rate ratio: 0.93, 95% confidence interval: 0.89-0.97) and a significantly lower proportion of boys (48.9%, P: = 0.02) compared with the general population (51.3%). The reduction in fertility was more pronounced in men with non-seminoma but the reduction in offspring sex ratio was independent of histological type. This confirms earlier results from less conclusive studies and indicates that testicular cancer, male subfertility and a female-biased sex ratio among new-born infants are characteristics of male reproduction that are linked by biological mechanisms.
Hum Reprod 2000 Sep
PMID:Fertility and offspring sex ratio of men who develop testicular cancer: a record linkage study. 1096 94

Subfertility in men is a heterogeneous syndrome, its pathophysiology remaining unknown in the majority of affected men. A large number of genes and loci are associated with sterility in experimental animals, but the human homologues of most of these genes have not been characterized. A British study suggested that, in a large proportion of men with idiopathic infertility, the disorder is inherited as an autosomal recessive trait; this provocative hypothesis needs confirmation. Because normal germ cell development requires the temporally and spatially co-ordinated expression of a number of gene products at the hypothalamic, pituitary and testicular levels, it is safe to predict that a large number of autosomal, as well as X- and Y-linked, genes will probably be implicated in different subsets of male subfertility.
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Sep
PMID:The genetic basis of infertility in men. 1109 81

Among the most popular techniques of assisted reproduction for the treatment of male subfertility and infertility are intrauterine insemination, in vitro fertilization and intracytoplasmic sperm injection. The objective of these techniques is to bring more functional spermatozoa closer to the oocyte in order to promote fertilization. These techniques are thus not a cure per se and are only indicated when no specific or effective treatment is available for the male partner, when this treatment has failed or when the improvement of the female fertility status has also failed. While for moderate oligoasthenozoospermia, intrauterine insemination has proved to be a valid treatment, the outcome after conventional in vitro fertilization is limited because of a high incidence of complete fertilization failure. Since the introduction of intracytoplasmic sperm injection, a reliable method has become available in order to achieve fertilization in vitro. Apart from well from ejaculated spermatozoa, epididymal or testicular spermatozoa too can be used successfully for intracytoplasmic sperm injection. The surgical retrieval of spermatozoa for intracytoplasmic sperm injection has therefore become a routine technique in clinical andrology. Although these techniques have been implemented in everyday infertility practice within a few years of their introduction, many concerns about safety continue to exist. Intracytoplasmic sperm injection must be applied with caution, only when no other treatment option is available and when an appropriate prospective follow-up of the offspring is available.
Baillieres Best Pract Res Clin Endocrinol Metab 2000 Sep
PMID:Management of male infertility by assisted reproductive technologies. 1109 84

Male subfertility is a growing reason for assisted reproduction. A limiting factor in male subfertility is asthenospermia. Motility is a cardinal indication of sperm vitality. Thus prognostic assays are aimed at quantitative determination of progression to assess the fertilising potential. However, a method permitting reliable prognosis of the fertilising capacity has yet to be developed. The assay presented here is the outcome of empirical data based on 590 IVF (in vitro fertilisation) trials. It is essentially a further exploitation of the Swim Up procedure, the selected sperms being maintained in culture under identical conditions employed in IVF. Semi-quantitative daily recordings of linear progression until complete extinction provided an index on vitality which is directly related to the fertilising potential. The findings indicated that a threshold of 50% linear motility after 24 hr culture was required to initiate fertilisation. The fertilising potential was guaranteed when at least 60% linear motility was observed at 24 hr, making the assay a predictive one. Its simplicity is an attractive feature.
Indian J Exp Biol 2000 Sep
PMID:Fertilising capacity of human sperms: a simple predictive assay. 1256 56

The correlation between sperm motion characteristics and in vitro fertilization was studied in 160 cycles, divided in two groups: those with male subfertility (N=42) and those with tubal disease (N=118). The group with male subfertility showed inferior performance, as indicated by a lower fertilization rate per oocyte (40% versus 66%) and per pick-up cycle (67% versus 93%). These two groups exhibited no significant difference in the mean sperm velocity, linearity, amplitude of lateral head displacement, and beat cross frequency in the pre swim-up and post swim-up specimens. The two groups differed in pre and post swim-up sperm motility, pre and post swim-up concentration, pre swim-up cumulative velocity at 110 to 140 Amicrom/sec and post swim-up cumulative velocity at 130 microm/sec. Logistic regression analysis was used to determine those variables that would predict fertilization; pre swim-up count and post swim-up motility proved to be the significant determinants. The results indicate that assessment of motion by automated semen analyzers does not supplement conventional semen analysis in the ability to predict fertilization.
Ann Saudi Med 1994 Sep
PMID:Predictive power of sperm motion analysis in in vitro fertilization. 1758 46

The objective of this study was to determine whether sperm quality, fertilization capacity, and subsequent embryo development are altered in diabetic male mice and whether differences in facilitative glucose transporter (GLUT; now known as solute carrier family 2, SLC2A) expression in the testis and sperm exist. Using two type 1 diabetic mouse models, SLC2A expression in the testis and sperm was determined by western immunoblotting and immunofluorescence staining. To address sperm quality and fertilization capacity, computer-assisted sperm analysis and in vitro fertilization were performed. SLC2A1, SLC2A3, and SLC2A5 did not change in expression in the testes or sperm between diabetic and non-diabetic mice. SLC2A8 and SLC2A9b were less expressed in the testes of both diabetic models versus controls. SLC2A9a was not expressed in the Akita testis or sperm when compared with strain-matched controls. 3beta-hydroxysteroid dehydrogenase (HSD3B) expression was significantly decreased in the Leydig cells from the diabetic mice. Sperm concentration and motility were significantly lower in both the diabetics when compared with the control. These parameters normalized in Akita diabetic males treated with insulin. In addition, fertilization rates were significantly lower in the Akita group (17.9%) and the streptozotocin (STZ)-injected male group (43.6%) when compared with the normal group (88.8%). Interestingly, of the fertilized zygotes, embryo developmental rates to the blastocyst stage were lower in both diabetic models (7.1% Akita and 50.0% STZ) when compared with controls (71.7%). Male diabetes may cause male subfertility by altering steroidogenesis, sperm motility, and SLC2A expression. This is the first study to link a paternal metabolic abnormality to a sperm effect on cell division and subsequent embryonic development.
Reproduction 2008 Sep
PMID:Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression. 1855 60


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