Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0848676 (male subfertility)
 265 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to evaluate the association between male subfertility and the subsequent risk of testicular cancer, a population-based case-control study was conducted in The Danish population. Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population using the computerized Danish Central Population Register. The men were interviewed by telephone; 514 cases and 720 controls participated. A reduced risk of testicular cancer was associated with paternity (relative risk = 0.63; 95% confidence interval: 0.47-0.85). In men who prior to the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (95% confidence interval: 1.43-2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma, and were not influenced by adjustment for potential confounding factors. These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.
 ...
PMID:[Occurrence of testicular cancer in subfertile men. A case-control study]. 1077 55

Analysis of associations between testicular cancer, subfertility and offspring sex ratio (proportion of males born among newborns) was performed on 3530 Danish men, born 1945-1980, who developed testicular cancer in the period 1960-1993. As the basis of comparison we used the total population of Danish men born in the period 1945-1980 (n = 1 488 957) and their biological children (n = 1 250 989). Men who developed testicular cancer had, prior to the cancer diagnosis, a reduced fertility (standardized fertility rate ratio: 0.93, 95% confidence interval: 0.89-0.97) and a significantly lower proportion of boys (48.9%, P: = 0.02) compared with the general population (51.3%). The reduction in fertility was more pronounced in men with non-seminoma but the reduction in offspring sex ratio was independent of histological type. This confirms earlier results from less conclusive studies and indicates that testicular cancer, male subfertility and a female-biased sex ratio among new-born infants are characteristics of male reproduction that are linked by biological mechanisms.
 ...
PMID:Fertility and offspring sex ratio of men who develop testicular cancer: a record linkage study. 1096 94

Previous studies have suggested an association between subfertility and testicular cancer by using fecundity and semen characteristics to measure fertility. The occurrence of twinning in offspring may be used to investigate male reproductive health, because dizygotic twinning is reduced by male subfertility. We therefore assessed number of children and offspring twinning rates among 4592 Swedish patients with testicular cancer and 12 254 control subjects. Before diagnosis, case patients had a decreased number of children (for testicular cancer, odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.62 to 0.81; at least three children compared with no children), with a lower frequency of dizygotic twinning (for unlike-sex twins, OR for the father having testicular cancer = 0.49, 95% CI = 0.22 to 1.08). The ratio of unlike-sex to same-sex twins was 0.22 among children of case patients and 0.66 among children of control subjects (adjusted P =.03, two-sided Wald test). We also found an increased occurrence of twinning after diagnosis, probably attributable to treatment for iatrogenic subfertility. Our study strongly supports evidence of an association between subfertility and the subsequent risk for testicular cancer.
 ...
PMID:Fecundity and twinning rates as measures of fertility before diagnosis of germ-cell testicular cancer. 1473 4

The potential health impact of pharmaceutical waste is now a growing concern. Contraceptive steroids are prominent environmental contaminants and thus may act as endocrine disruptors. Numerous xenobiotics hamper Sertoli cells junctional communication which is known to participate in spermatogenesis control. This has been associated with male subfertility and testicular cancer. We investigated three contraceptive molecules found in the environment for their potential impact on Sertoli cells gap junction functionality: 17a-ethynylestradiol, medroxyprogesterone acetate and levonorgestrel. Four other non-steroid drugs also found in the environment were included in the study. Communication disruption was analyzed in vitro in murine seminiferous tubules and the 42GPA9 Sertoli cell line. Steroids modulated connexin43 trafficking and impaired junctional communication through rapid effects apparently acting on the cell membrane but not on Cx43 expression. The 4 non-steroid compounds showed no effect. Longer exposure to steroids increased gap junction impairment, which was associated in part with Na/K ATPase internalization. Estrogen receptors (ER) did not appear to be involved in gap junction disruption: Sertoli cells are devoid of ERalpha and only express the cytoplasmic beta isoform. ERbeta localization was not modified by either steroid. The threshold level was surprisingly low, around 10(-16) M. We conclude that steroidal pollutants disrupt Sertoli cells junctional communication in vitro at concentrations that can be found in the environment.
 ...
PMID:Contraceptive steroids from pharmaceutical waste perturbate junctional communication in Sertoli cells. 1977 77

In recent years approximately 8% of the newborn Danes have been conceived by infertility treatment, and approximately half of the cases are due to male subfertility. Male infertility can be caused by several factors, and only in about half of the cases is it possible to disclose an aetiological explanation. It is important to elucidate possible reasons for male infertility as low semen quality might be a symptom of pituitary dysfunction, genetic disorders or testicular cancer.
 ...
PMID:[Male infertility]. 2305 Jun 83