Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0848576 (breast hyperplasia)
 35 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyperplasia and carcinoma in situ of the breast are thought to be non-obligatory precursor lesions of invasive breast carcinoma. Such lesions are detected more and more through mammography. A subjective, clinically relevant histopathological classification system of preinvasive breast lesions has been established by Page and co-workers in large groups of patients with long term follow-up. Attempts have been made to objectify the changes within the different preinvasive entities using quantitative techniques. Furthermore, some clues have been found as to the molecular background of breast oncogenesis. In this paper, an overview of possible surrogate endpoint biomarkers of breast hyperplasia and carcinoma in situ is presented.
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PMID:Biomarkers of breast hyperplasias and in situ carcinomas: an overview. 782 13

Hyperplasia of mammary glands (HMG) is also termed mammary dysplasia. In China, the number of patients suffering from breast hyperplasia is increasing annually. MicroRNAs (miRNAs; length, 19-24 nucleotides), a group of small endogenous non-coding RNAs, post-transcriptionally regulate gene expression via RNA interference and gene silencing pathways. The cause of disease of HMG because remains unclear. Thus, the aim of the present study was to establish comprehensive profile of drug treatments following at different time intervals on rat models of differentially expressed miRNAs, using miRNA microarray data. After scanning the chip, 13 up-regulated and 20 down-regulated miRNAs were identified. MiR-31 and miR-30 exhibited different expression levels between rats exhibiting mammary gland hyperplasia treated with or without Jiedu Capsule water solution once a day for 4 weeks, and the two demonstrated a strong association with HMG and breast cancer. Therefore, the functions of these miRNAs may provide the basis for further investigation of HMG.
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PMID:MicroRNA array analysis of the regulation of microRNAs in rats exhibiting hyperplasia of mammary glands. 2996 6