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Query: UMLS:C0848332 (Spots)
 453 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Usefulness of endoscopic ultrasonography (EUS) for the diagnosis of chronic pancreatitis, particularly for mild chronic pancreatitis and so-called clinically suspected chronic pancreatitis diagnosed by the criteria documented by the Committee of Japanese Society of Gastroenterology for chronic pancreatitis (CJSG criteria), is described in this paper. 89 patients with chronic pancreatitis including 43 with mild chronic pancreatitis (MIP), 29 with moderate chronic pancreatitis (MOP) and 17 with advanced chronic pancreatitis (ADP) diagnosed by Endoscopic Retrograde Cholangio-Pancreatography (ERCP) were selected for the study and following results were obtained. 1) The number of findings of wall irregularity of the main pancreatic duct and heterogeneity of the pancreatic parenchyma were more clearly shown by EUS although they had been classified as suspicious of chronic pancreatitis diagnosed by conventional US by the CJSG criteria. 2) The pancreatic parenchymal echo pattern by EUS can be divided into 6 patterns, rough-high echo, spotty-high echo, linear-high echo, rough-low echo, diffuse-high echo and diffuse-low echo. 3) Spotty high echo was observed in high rate in the patients even with MIP showing only a slight change of the main pancreatic ducts by ERCP. Therefore, this pattern could be present in early stage of chronic pancreatitis. 4) The pancreatic parenchymal change by aging detected by EUS was often seen as linear-high and/or diffuse-high echo patterns. 5) Differentiation of changes of the pancreatic parenchyma and wall of the main pancreatic duct by chronic pancreatitis from the change by aging was possible by using EUS. 6) By macro- and micro-scopic studies of the pancreatic parenchyma, pancreatic calculus, fatty change and irregular fibrosis were shown by EUS as rough-high echo accompanied by acoustic shadow, spotty-high echo and rough-low echo patterns respectively.
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PMID:[Clinical evaluation of endoscopic ultrasonography in diagnosis of chronic pancreatitis]. 152 43

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by rapid progression, invasiveness, and resistance to treatment. It is the fourth leading cause of cancer death with a 2% 5-year survival rate. Biomarkers for its early detection are lacking. This study was designed to use a proteomics-based approach as a means of identifying antigens that elicit a humoral response in PDAC patients. Antibodies against PDAC-associated antigens are useful for early cancer diagnosis and therapy. Proteins from PDAC cell lines were separated by 2-DE, and the serum IgG reactivity of 70 PDAC patients, 40 healthy subjects (HS), 30 non-PDAC tumor patients, and 15 chronic pancreatitis (CP) patients was tested by Western blot analysis. Spots specifically recognized by PDAC sera and revealed by mass spectrometry corresponded to metabolic enzymes or cytoskeletal proteins. Most were up-regulated in PDAC tissues. Thus, it seems that metabolic enzymes and cytoskeletal proteins are specific targets of the humoral response during PDAC. The results of further studies of these serological-defined antigens could be of diagnostic and therapeutic significance in PDAC.
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PMID:Autoantibody signature in human ductal pancreatic adenocarcinoma. 1782 82