Gene/Protein Disease Symptom Drug Enzyme Compound
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 453 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results of bacteriological cultures taken from the IUDs of 54 women who wanted them removed for various reasons was a correlation between positive cultures and symptoms of pain and metrorrhagia. Hypermenorrhea was not recorded or correlated to findings. In 18 cases where symptoms in the women were correlated to findings of pathogenic cultures, the male consorts were examined as a possible source of infection. In the 14 women who were free of symptoms, there were 7 negative cultures. In the 40 women who had symptoms of pain and metrorrhagia, 35 had positive cultures. Correlation to symptoms showed that in 15 cases there was both pain and intermenstrual bleeding. 13 cases had bleeding only and in 12 cases there was pain only. 4 of the women who had complained of pain and bleeding previously had negative cultures at the time of the removal of the IUD. They had received antibiotics before the IUD removal, and then pain and bleeding had stopped when taking or soon after taking antibiotics. The sterile cultures represented 50% of the symptom-free patients but only 10% of the cases with symptoms. Further, streptococci were only found in patients with symptoms, where they were present in 55% of the cultures. Also, the enterobacteria were largely confined to specimens from patients with symptoms. This strongly indicates that intrauterine infection contributed to the clinical picture in most cases. In conclusion, IUDs enhance the fibrinolytic activity of the endometrium, resulting in an insufficient hemostasis of the microtraumata caused by the IUD. Spotty bleeding and menorrhagia favor bacterial invasion resulting in endometritis and in turn increased bleeding and pain. IUDs releasing inhibitors of fibrinolysis might be an approach to eliminate the bleeding problem and thereby infection and pain.
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PMID:Bacterial infection in relation to pain and irregular bleeding in women using IUD. 38 99