Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0848237 (acute stress)
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Human Gene/Protein
HNRPC 11.2
folate receptor 2 11.2
HNRPF 10.8
ARHB 10.8
RAB4A 10.2
G3BP protein 10.2
down-regulated in renal cell carcinoma 1 10.2
POLR2B 9.9
transcription factor 15 9.9
growth hormone 2 9.8
neuronal tryptophan hydroxylase 9.2
GPX4 protein 9.2
Peripheral benzodiazepine receptor 8.9
cornulin 8.8
adenylate cyclase 5 8.8
DBK 8.8
densin-180 8.8
CORT 8.7
PMCH 8.7
PRPS2 8.7
matrilin-4 8.7
RDH8 8.6
MCFP 8.5
MAGE-B2 8.4
guanylate kinase-associated protein 8.4
CRF-binding protein 8.3
CHRDL1 8.3
PPSH 8.3
CRFR 8.2
ATP synthase 6 8.2
HUP1 8.2
HYOU1 8.1
histone deacetylase 11 8.0
fructose-1,6-bisphosphatase 1 8.0
GPR158 7.9
Noc2 7.9
PIK3IP1 7.9
NCCRP-1 7.9
corticosteroid binding globulin 7.9
Nrf3 7.8
HPA 7.8
cytoskeleton associated protein 7.8
early growth response 3 7.8
CRHR2 7.7
melanocortin-5 receptor 7.7
amylase 1 7.7
QSOX1 7.7
CRFR1 7.7
voltage-dependent anion channel 2 7.7
TPO1 7.7
PSMA1 7.7
TRM6 7.6
RGS4 protein 7.6
SCARA5 7.6
UCN2 7.6
F13A 7.6
secretagogin 7.6
cystine/glutamate transporter 7.5
GCN5L1 7.5
HSPB2 7.5
organic cation transporter 3 7.5
KCTD12 7.4
BFD 7.4
Tip110 7.4
NPAS4 7.4
PGC1A 7.4
NUCB2 7.4
corticotropin-releasing factor receptor 7.4
CPEB3 7.3
PSA1 7.3
Abelson helper integration site 1 7.3
ST8SIA2 7.3
arachidonate 15-lipoxygenase 7.3
CRHR1 7.3
5HT1a 7.3
Cyclin-dependent kinase inhibitor 7.3
Heat shock transcription factor 1 7.3
CRH 7.2
CRTC 7.2
SUV39H2 7.2
BBH 7.2
corticotropin-releasing factor 7.2
STRAP 7.1
M40 7.1
PDE1B 7.1
CRF-BP 7.1
PFK-2/FBPase-2 7.1
PRDX4 7.1
orexin receptor-1 7.0
MLN64 7.0
Lay 7.0
CRF1 7.0
HSF2 6.9
HSP90B1 6.9
ICS1 6.9
GLUC 6.9
AFG3L2 6.9
SgII 6.9
SOD2 protein 6.9
3-beta-hydroxysteroid dehydrogenase 6.9
hyaluronan binding protein 6.8
LVV-hemorphin-7 6.8
EPO-R 6.8
p45 NF-E2 6.8
BOM 6.8
V1a vasopressin receptor 6.8
PNMT 6.8
CRF2 6.7
GRM7 6.7
EPAC2 6.7
Spn 6.7
USP2 6.7
carbonic anhydrase VI 6.7
mGlu7 6.7
urocortin 3 6.7
Prolactin-releasing peptide 6.7
CREB3 6.6
adrenocorticotropic hormone 6.6
SAP2 6.5
nuclear transporter 6.5
cyclin-dependent kinase inhibitor 1B 6.5
Diaphorase 6.5
G3BP1 6.5
melanocortin 2 receptor 6.5
SSD1 6.5
CR6 6.5
MEKK4 6.5
benzodiazepine receptor ligand 6.5
Neuregulin 1 6.5
Relaxin-3 6.4
Period 3 6.4
5-HT-1A 6.4
KLRG1 6.4
cystatin S 6.4
Hsp70-interacting protein 6.4
Ino80 6.4
COPE 6.3
SLC6A2 6.3
MyD118 6.3
JCH 6.3
SP-2 6.3
glucocorticoid receptor 6.3
GPB 6.3
CRF 6.3
Tuba 6.3
activity-regulated cytoskeleton-associated protein 6.3
Proopiomelanocortin 6.3
urocortin 6.3
V1aR 6.2
ABCC9 6.2
CGB 6.2
HSP-60 6.2
somatostatin receptor 2 6.2
G3BP 6.2
TRKB 6.2
Jun dimerization protein 2 6.2
Kv7.3 6.2
mGlu1 6.2
CD200R 6.2
mGlu2 6.2
more...
Disease
Euthymic mood 12.8
Chromodacryorrhea 11.2
Dennie-Morgan fold 10.8
Acute stress disorder 10.8
Stockholm syndrome 10.4
Fetal hemorrhage 9.9
Psychotic episodes 9.9
Muehrcke's lines 9.4
sympatheticotonia 9.4
social stress 9.1
IHG 8.8
brief reactive psychosis 8.5
Hutchinson's sign 8.3
Psychiatric emergencies 8.2
war neurosis 8.2
DSAP 8.1
HPA 7.8
Lacunar infarction 7.8
psychological stress 7.8
Dietary zinc deficiency 7.5
adjustment disorder 7.5
Insulin hypoglycemia 7.4
Autonomic imbalance 7.4
derealization 7.3
Neonatal encephalopathy 7.2
adjustment reaction 7.2
Verbal abuse 6.9
IMO 6.9
porcine stress syndrome 6.9
Ganser syndrome 6.9
posttraumatic stress disorder 6.8
Traumatic Stress Disorder 6.8
chafing 6.7
Uta 6.7
AEI 6.6
flashbacks 6.5
emotional stress 6.4
emotional trauma 6.4
Acute encephalopathy 6.4
cerebral hematoma 6.4
Nicotine withdrawal 6.4
Chronic insomnia 6.3
Takotsubo syndrome 6.3
fugue 6.2
Acute myocardial ischemia 6.1
eosinopenia 6.1
hypercortisolemia 6.0
Wyeomyia 6.0
stress ulcer 5.9
Oppenheim 5.9
organic psychosis 5.9
Autonomic dysreflexia 5.8
anhedonia 5.8
postconcussional syndrome 5.7
Expressed Emotion 5.7
early disease onset 5.6
Addisonian crisis 5.6
poison ivy 5.5
separation anxiety disorder 5.5
exhibitionism 5.5
trance 5.5
intermittent explosive disorder 5.5
Stereotypy 5.4
Aeromonas hydrophila infection 5.4
idiopathic disorder 5.4
anxiety state 5.4
emotionality 5.3
anxiety disorders 5.3
Behavioral problems 5.3
sleepwalking 5.3
neurodermatitis 5.3
Bielschowsky 5.2
somatization disorder 5.2
stereotypies 5.2
coprophagy 5.2
panic attacks 5.1
PIT 5.1
OBX 5.1
psychogenic disorders 5.0
psychomotor impairment 5.0
nostalgia 5.0
NSD 5.0
neurogenic hypertension 5.0
Scheie 5.0
Functional dyspepsia 4.9
physical disorders 4.9
postpartum psychosis 4.8
psychosomatic disorders 4.8
panic disorder with agoraphobia 4.8
identity disorder 4.8
HP2 4.8
agoraphobia 4.8
Koebner 4.8
IS3 4.7
psychological distress 4.7
reactive depression 4.7
MacLeod 4.7
Somatization 4.7
GAD 4.6
depersonalization 4.6
perseveration 4.6
behavior problem 4.6
FSS 4.6
fear and anxiety 4.6
Mallory-Weiss syndrome 4.6
low IQ 4.6
binge eating 4.6
major depressive disorder 4.5
gastric ulcer 4.5
rumination 4.5
hypermagnesemia 4.4
interstitial cystitis 4.4
DMS 4.4
dissociative disorder 4.4
phobia 4.4
emotional abuse 4.4
Li-Fraumeni syndrome 4.4
OFC 4.3
Pituitary 4.3
Meadow 4.3
CVS 4.3
urticaria pigmentosa 4.3
tension headache 4.3
panic disorder 4.2
emotional distress 4.2
SD1 4.2
Victimization 4.2
cocaine addiction 4.2
cardiosclerosis 4.2
thyroid storm 4.2
multiple personality disorder 4.1
hypersexuality 4.1
FFI 4.1
memory impairment 4.1
AOA 4.1
atrial septal defect 4.1
clinical depression 4.1
kwashiorkor 4.1
dermatofibroma 4.0
wasting syndrome 4.0
PND 4.0
HSP 4.0
neuroticism 4.0
depression 4.0
hypercortisolism 4.0
Refsum disease 4.0
Atopic 4.0
cold 4.0
CHR 3.9
SCP 3.9
Bullying 3.9
substance use disorders 3.9
premenstrual dysphoric disorder 3.9
HPC 3.9
sexual assault 3.8
adrenal insufficiency 3.8
induced psychosis 3.8
transient global amnesia 3.8
LMS 3.8
LMS 3.8
more...
Symptom
acute stress 12.8
Auspitz's sign 10.4
Osler's nodes 8.1
not coping 7.5
Koplik spots 7.4
stomach distension 7.4
Darier's sign 7.1
Beau's lines 7.0
Grimace 6.7
PAIN 6.6
Subjective tinnitus 6.6
Inflammatory pain 6.5
physical exhaustion 6.4
situational stress 6.4
sighing 6.2
Chronic pelvic pain 6.1
despair 5.8
startle reaction 5.5
Neurologic symptoms 5.2
Spots 4.9
hopelessness 4.7
prostatism 4.6
Depressive symptoms 4.4
loss of taste 4.2
acute pain 4.1
loss of balance 3.9
Halo 3.9
ketonuria 3.6
insomnia 3.6
exhaustion 3.5
hunger 3.5
analgesia 3.4
chronic back pain 3.2
rigors 3.1
alexithymia 3.0
distraction 2.9
joint stiffness 2.7
microbial colonization 2.7
catatonia 2.6
memory loss 2.5
hyperoxia 2.4
starvation 2.4
Sedation 2.4
Neuropathic pain 2.3
skin damage 2.2
anosmia 2.2
physical appearance 2.2
hypothermia 2.1
menopausal symptoms 2.1
bloating 2.0
incoordination 2.0
cachexia 1.9
acute abdominal pain 1.8
hypercapnia 1.8
pelvic pain 1.8
discomfort 1.8
twitching 1.8
blurred vision 1.7
pain 1.7
chest pain 1.7
myalgia 1.7
tinnitus 1.6
polydipsia 1.6
fatigue 1.6
agitation 1.5
dizziness 1.5
collapse 1.4
anesthesia 1.4
tremor 1.4
anorexia 1.3
seizures 1.3
colic 1.1
discomfort 1.1
overweight 1.1
stigma 1.0
acidity 0.9
shortness of breath 0.4
Ill 0.3
erythema 0.1
functional recovery 0.0
headache -0.0
arthralgia -0.1
spasm -0.1
abdominal pain -0.2
ataxia -0.2
dystonia -0.3
syncope -0.4
dyspnea -0.4
respiratory distress -0.5
low back pain -0.5
angina -0.6
cough -0.8
sleepiness -0.9
vomiting -1.2
diarrhea -1.5
nausea -1.8
weakness -2.5
Drug
Typhoid vaccine 9.3
Naloxone HCl 9.1
Adinazolam 7.9
Lumiracoxib 7.1
Cortrosyn 6.8
Cortrosyn 6.6
Indoxacarb 6.5
Atosiban 6.5
hCRH 6.5
Tianeptine 6.4
Thymopentin 6.4
Cilnidipine 6.3
Agomelatine 6.2
Paliperidone 6.0
CMX 6.0
Proglumide 5.8
Prozac 5.8
Lugol's solution 5.8
Nadolol 5.4
Atomoxetine 5.0
Finasteride 5.0
Pitressin 4.7
Sucralfate 4.6
Pregnenolone 4.6
DEX 4.5
Indapamide 4.3
Tocilizumab 4.0
Reserpine 3.8
GHRP 3.6
Diurnal 3.6
9-THC 3.6
Portal 3.5
CFS 3.4
Lovastatin 3.4
Triad 3.3
IL-1ra 3.3
Frontal 3.3
Camp 3.3
ICI 3.2
Clonidine 3.1
Cimetidine 3.1
Cimetidine 3.1
Photofrin 2.9
DDAVP 2.8
DDAVP 2.8
Sodium nitroprusside 2.8
Salbutamol 2.7
Luteinizing 2.7
CTC 2.7
Atropine 2.6
CDP 2.6
Phentolamine 2.5
EPA 2.5
CTC 2.4
Scopolamine 2.4
Nephron 2.3
Ethanol 2.3
Growth hormone 2.2
Growth hormone 2.2
Ranitidine 2.1
TAC 2.1
Angiotensin II 2.0
HCH 2.0
Award 2.0
IL-2 1.9
Parkin 1.9
Parkin 1.9
Glucagon 1.9
niacin 1.9
EE2 1.8
Bifidobacterium 1.8
Itraconazole 1.8
uPA 1.7
EPI 1.7
PCB 1.7
Captopril 1.6
ROS 1.5
MAP 1.4
AZT 1.4
Glutathione 1.4
ETA 1.3
Alanine 1.3
Ringer's solution 1.3
Mutagen 1.2
AZT 1.2
Vitamin A 1.2
caffeine 1.2
Heme 1.1
Leaf 0.9
IFN-gamma 0.7
lactose 0.7
nitroglycerin 0.6
Gel 0.5
FAD 0.3
Histamine 0.3
ascorbate 0.3
ZnO 0.0
Monit -0.0
CSF -0.2
ROC -0.2
lysine -0.3
ENT -0.3
citric acid -0.5
NADH -0.7
TiO2 -0.7
Nephron -0.8
Asthma -0.9
Cardiovasc -2.0
Dermatol -2.2
Enzyme
serine dehydrogenase 9.8
HPI 6.8
GSase 6.8
isoflavone reductase 6.4
hydroxyprostaglandin dehydrogenase 6.1
neuropsin 6.1
oxytocinase 5.9
trehalose synthase 5.6
ATP diphosphohydrolase 5.5
alpha-amylase 5.4
neuropsin 5.4
3alpha-hydroxysteroid dehydrogenase 5.3
tryptophan hydroxylase 5.1
phenylethanolamine N-methyltransferase 5.1
5alpha-reductase 5.0
5alpha-reductase 5.0
monoacylglycerol lipase 4.9
sulfhydryl oxidase 4.8
ADPase 4.7
SpeB 4.6
dopamine beta-hydroxylase 4.6
phospholipid hydroperoxide glutathione peroxidase 4.3
TMT 4.1
HCS 4.1
tyrosine aminotransferase 4.0
beta-amylase 4.0
SCP 3.9
tyrosine hydroxylase 3.9
3beta-hydroxysteroid dehydrogenase 3.9
angiotensin-converting enzyme 2 3.8
nucleotidase 3.7
ECH 3.7
arginine decarboxylase 3.7
glutamate decarboxylase 3.7
arginine decarboxylase 3.5
PDH 3.3
phosphoenolpyruvate carboxykinase 3.3
phosphoenolpyruvate carboxykinase 3.3
histidine decarboxylase 3.2
apyrase 3.2
phosphoenolpyruvate carboxykinase 3.2
TACE 3.1
PHD 3.0
tryptophan 2,3-dioxygenase 3.0
S-adenosylmethionine decarboxylase 3.0
LasR 2.9
MEKK1 2.9
cholesterol esterase 2.9
BIS 2.8
GSK 2.8
creatine kinase 2.8
SCS 2.8
DOPA decarboxylase 2.7
hormone-sensitive lipase 2.7
15-lipoxygenase 2.6
TSA 2.5
NOS 2.5
xanthine dehydrogenase 2.5
CPS 2.4
cholinesterase 2.4
superoxide dismutase 2.4
11beta-hydroxysteroid dehydrogenase 2.4
CaMKII 2.4
LPL 2.3
DNA ligase 2.3
DNA ligase 2.3
glutathione peroxidase 2.3
heme oxygenase 2.3
indoleamine 2,3-dioxygenase 2.3
3-hydroxy-3-methylglutaryl coenzyme A reductase 2.2
TOR 2.2
citrate synthase 2.2
AST 2.2
monoamine oxidase 2.2
sialyltransferase 2.2
glucose-6-phosphatase 2.2
sialyltransferase 2.2
sialyltransferase 2.2
5'-nucleotidase 2.1
STR 2.1
paraoxonase 2.0
HSD 2.0
catalase 2.0
pyruvate kinase 2.0
hexokinase 2.0
acetylcholinesterase 2.0
MAP 1.9
glutathione reductase 1.9
adenylate kinase 1.8
lysozyme 1.8
DCF 1.8
aspartate aminotransferase 1.8
cathepsin D 1.7
paraoxonase 1.7
matrix metalloproteinase 9 1.6
ADH 1.6
PDK1 1.6
NO synthase 1.6
tissue plasminogen activator 1.6
histidine kinase 1.5
IKK 1.5
mitogen-activated protein kinase 1.5
CDR 1.5
glutamine synthetase 1.4
peroxiredoxin 1.4
sialidase 1.4
PARP 1.3
histone acetyltransferase 1.3
caspase-3 1.3
renin 1.3
diaphorase 1.3
demethylase 1.3
tryptase 1.3
phosphorylase 1.3
ascorbate peroxidase 1.3
glucokinase 1.3
protein kinase C 1.3
caspase-1 1.1
choline acetyltransferase 1.1
ornithine decarboxylase 1.1
CPT 1.1
proteasome 1.1
protein kinase 1.1
granzyme B 1.1
isocitrate dehydrogenase 1.0
CPT 1.0
pyruvate dehydrogenase 1.0
pyruvate dehydrogenase 1.0
lactate dehydrogenase 0.9
arginase 0.9
phospholipase D 0.9
adenylate cyclase 0.8
phosphofructokinase 0.8
glucose-6-phosphate dehydrogenase 0.8
NADPH-diaphorase 0.8
cathepsin B 0.7
xanthine oxidase 0.7
MMP 0.7
calcineurin 0.7
AMP-activated protein kinase 0.7
CAD 0.7
cytochrome oxidase 0.6
PAH 0.6
CAD 0.6
plasmin 0.6
CAD 0.6
ACE 0.6
CPT 0.6
glyceraldehyde-3-phosphate dehydrogenase 0.6
beta-galactosidase 0.5
CD10 0.5
ATPase 0.5
chloramphenicol acetyltransferase 0.4
adenosine deaminase 0.4
NADPH oxidase 0.4
adenosine deaminase 0.4
alanine aminotransferase 0.4
RNase 0.3
pyruvate dehydrogenase 0.3
glyceraldehyde-3-phosphate dehydrogenase 0.3
more...
Compound
2-hydroxy-1-phenylethanone 10.4
3,21-dihydroxypregnan-20-one 10.2
2-hydroxy-1-phenylethanone 9.4
Prazepam 8.9
C16H34 8.4
PQM 8.2
3 PS 8.2
3-hydroxypregnan-20-one 7.9
3-hydroxypregnan-20-one 7.7
9(10H)-anthracenone 7.3
Corticosterone 7.3
Thujone 7.3
Nandrolone decanoate 7.1
Corticotropin 7.0
2-phenoxyethanol 6.9
N-acetylaspartic acid 6.8
N-acetylaspartic acid 6.6
Allopregnanolone 6.6
9(10H)-anthracenone 6.6
Cortisol 6.5
CHQ 6.5
NOP 6.5
Hydromorphone 6.4
Allopregnanolone 6.3
Hydrocortisone acetate 6.1
Pregnane 6.1
BQ 123 6.1
ACTH 6.1
Alprazolam 6.0
Rilmenidine 6.0
Betaxolol 5.9
N-F 5.8
Temazepam 5.8
3,5-T2 5.8
Ibotenic acid 5.6
Ibotenic acid 5.6
C 5 5.6
Polydatin 5.6
MHPG 5.5
Mepyramine 5.4
Dehydroepiandrosterone sulfate 5.4
Chlordiazepoxide 5.4
Meloxicam 5.4
Nandrolone 5.3
Fructosamine 5.3
Metyrapone 5.2
Metyrapone 5.2
fluorobenzene 5.2
Isatin 5.1
Bisoprolol 5.1
8-hydroxyguanosine 5.1
RU-486 5.0
Acetyl-L-carnitine 5.0
Selectin 4.9
Phosphorylcholine 4.9
heptanoic acid 4.8
Soman 4.8
Adrenal 4.8
Naltrexone 4.8
heptanoic acid 4.7
Sucralfate 4.7
3,4-Methylenedioxymethamphetamine 4.7
Allyl isothiocyanate 4.7
hydroxyindoleacetic acid 4.6
Diol 4.6
Ether 4.6
Ether 4.6
2-hexenal 4.6
Pregnenolone 4.6
DEX 4.5
PD 123319 4.5
IDP 4.5
Oxytocin 4.4
Etomidate 4.4
DBP 4.4
Amitriptyline 4.4
Sulindac 4.4
Quinolinic acid 4.3
DBP 4.2
TBT 4.2
N-(4-hydroxyphenyl)retinamide 4.2
Desmopressin 4.2
alpha-MSH 4.2
noradrenaline 4.2
aceturate 4.2
Candesartan 4.1
PAG 4.1
o,p'-DDD 4.1
PPF 4.1
Agmatine 4.1
AIR 4.1
Muscimol 4.1
FB2 4.1
Naloxone 4.1
Norepinephrine 4.1
DHA 4.0
Cocaine 4.0
Disodium cromoglycate 4.0
HPC 4.0
HPC 4.0
SP-1 4.0
malononitrile 3.9
5-HT 3.9
NBQX 3.9
MNA 3.9
MNA 3.9
Dexamethasone 3.9
BAS 3.8
APV 3.8
AMPA 3.8
5-HIAA 3.8
Picrotoxin 3.8
Picrotoxin 3.8
NFS 3.8
MPT 3.7
DNFB 3.7
DMS 3.7
Desipramine 3.7
Perna 3.7
Triiodothyronine 3.6
GABA 3.6
GABA 3.6
DSM 3.6
PGJ2 3.6
ECS 3.6
Carrageenan 3.6
alpha-Tocopherol 3.5
LTD 3.5
Etanercept 3.5
D-glucuronic acid 3.5
Hemin 3.4
Hemin 3.4
Hemin 3.4
Hemin 3.4
Naproxen 3.4
Tempol 3.4
NMDA 3.4
Ach 3.4
Diazepam 3.4
MSM 3.4
DOCA 3.4
gamma-hydroxybutyric acid 3.4
Propranolol 3.3
galanthamine 3.3
Dithiothreitol 3.3
MCH 3.3
1H-benzimidazole 3.3
Propranolol 3.3
Hemin 3.3
Tiron 3.3
Prazosin 3.3
Testosterone 3.2
DOC 3.2
Testosterone 3.2
Thyroxine 3.2
Chlorpyrifos 3.2
Metoprolol 3.2
SSD 3.2
Nembutal 3.2
TRH 3.1
more...